Chemomodulatory efficacy of Basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis

Dasgupta, Trisha; Rao, A.R.; Yadava, Pramod Kumar

doi:10.1078/0944-7113-00289

Cited by 73 publications

(36 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was via observed enhancing activity of liver SOD and reducing liver MDA contents which may have occurred by prevention of cell membrane lipids. This is attributed to the presence of numerous compounds in the leaves with high antioxidant content that scavenge the produced superoxide anion and hydroxylradicals (Dasgupta et al, 2004). High flavonoid contentsof this plant leaves may have contributed significantlyin line with Kostic et al (2013) that flavonoids have high antioxidant activities.…”

Section: Discussionmentioning

confidence: 87%

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

Uroko¹,

Adeyi²,

Hadiza³

et al. 2015

J. of Biological Sciences

View full text Add to dashboard Cite

A B S T R A C T This study evaluates qualitative and quantitative phytochemical properties ofAbrus precatorius leaves. The vitamins and therapeutic effect of methanol extract against tetrachloride (CCl 4 ) induced liver damage in male Wistar albino rats. The results of phytochemical and vitamins indicates richness in saponins, tannins, alkaloids and flavonoids with value 30.05±0.22%, while vitamins such as thiamine, riboflavin, niacin, antioxidant and vitamins A, C and E was quantified. The liver damage was observed in the animals with significant increase in ALT, AST and ALP following the in traperitoneal administration of CCl 4 . The methanol extract caused significant decrease (p<0.05) in the activities of these enzymes in the treated animals relative to positive control that received CCl 4 but were not treated. The extract showed potentials to mopping-up of free radicals generated by CCl 4 . The extract reduced lipid peroxidation in concentration dependent manner. The findings suggests that the extract have the capacity to improving liver functions and liver regeneration at high concentration. The extracts are safe for consumption, abundant phytochemicals and antioxidant vitamins could offer reasonable protections against oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 87%

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

Uroko¹,

Adeyi²,

Hadiza³

et al. 2015

J. of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…OB is commonly used in as culinary herbs in the Mediterranean region. Previous studies reveal the antimicrobial [19] , insecticidal [20] and anticarcinogenic [21] activities of different OB extracts. Furthermore, Ocimum sanctum possess antihyperglycaemic effect in alloxan-diabetic rats [22] .…”

Section: Discussionmentioning

confidence: 99%

Anti-hyperglycaemic and Hypolipidemic Effects of Ocimum basilicum Aqueous Extract in Diabetic Rats

Zeggwagh¹,

Sulpice²,

Eddouks³

2007

American J. of Pharmacology and Toxicology

View full text Add to dashboard Cite

Abstract:The hypoglycaemic and hypolipidemic effects of the aqueous extract of Ocimum basilicum (OB) whole plant were investigated in normal and streptozotocin (STZ) diabetic rats. After a single oral administration, OB significantly reduced blood glucose levels in normal (p<0.01) and diabetic rats (p<0.001). After 15 days of repeated oral administration, OB produced a potent reduction on blood glucose levels (p<0.001) in diabetic rats and a less reduction in normal rats (p<0.05). Total plasma cholesterol and triglycerides levels were significantly reduced after repeated oral administration in diabetic rats (p<0.001) and (p<0.05) respectively. However, no change was observed in total plasma cholesterol and triglycerides levels in normal rats after both single and repeated oral administration. In addition, plasma insulin levels and body weight remained unchanged over 15 days of oral administration in normal and diabetic rats. We conclude that the aqueous extract of OB exhibits potent anti-hyperglycaemic and hypolipidemic activities in diabetic rats without affecting basal plasma insulin concentrations.

show abstract

“…Sweet basil has been extensively used for centuries in traditional medicine for the treatment of various ailments (Bilal et al, 2012). Several pharmacological studies have demonstrated that sweet basil contains biologically active constitutions that are analgesic, anti-inflammatory, antimicrobial, antioxidant, antiulcerogenic, anticarcinogenic, cardiac stimulant, chemomodulatory, central nervous system depressant, hepatoprotective, hypoglycemic, hypolipidemic, immunomodulatory, and larvicidal (Dasgupta et al, 2004;Muralidharan and Dhananjayan, 2004;Lee et al, 2005;Zeggwagh et al, 2007;Meera et al, 2009;Zhang et al, 2009;Arshad Qamar et al, 2010;Choudhury et al, 2010;Dashputre and Naikwade, 2010;Fathiazad et al, 2012).…”

mentioning

confidence: 99%

Methyl Jasmonate-Elicited Transcriptional Responses and Pentacyclic Triterpene Biosynthesis in Sweet Basil

et al. 2013

View full text Add to dashboard Cite

Sweet basil (Ocimum basilicum) is well known for its diverse pharmacological properties and has been widely used in traditional medicine for the treatment of various ailments. Although a variety of secondary metabolites with potent biological activities are identified, our understanding of the biosynthetic pathways that produce them has remained largely incomplete. We studied transcriptional changes in sweet basil after methyl jasmonate (MeJA) treatment, which is considered an elicitor of secondary metabolites, and identified 388 candidate MeJA-responsive unique transcripts. Transcript analysis suggests that in addition to controlling its own biosynthesis and stress responses, MeJA up-regulates transcripts of the various secondary metabolic pathways, including terpenoids and phenylpropanoids/flavonoids. Furthermore, combined transcript and metabolite analysis revealed MeJA-induced biosynthesis of the medicinally important ursane-type and oleanane-type pentacyclic triterpenes. Two MeJAresponsive oxidosqualene cyclases (ObAS1 and ObAS2) that encode for 761-and 765-amino acid proteins, respectively, were identified and characterized. Functional expressions of ObAS1 and ObAS2 in Saccharomyces cerevisiae led to the production of b-amyrin and a-amyrin, the direct precursors of oleanane-type and ursane-type pentacyclic triterpenes, respectively. ObAS1 was identified as a b-amyrin synthase, whereas ObAS2 was a mixed amyrin synthase that produced both a-amyrin and b-amyrin but had a product preference for a-amyrin. Moreover, transcript and metabolite analysis shed light on the spatiotemporal regulation of pentacyclic triterpene biosynthesis in sweet basil. Taken together, these results will be helpful in elucidating the secondary metabolic pathways of sweet basil and developing metabolic engineering strategies for enhanced production of pentacyclic triterpenes.

show abstract

Chemomodulatory efficacy of Basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis

Cited by 73 publications

References 43 publications

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

Anti-hyperglycaemic and Hypolipidemic Effects of Ocimum basilicum Aqueous Extract in Diabetic Rats

Methyl Jasmonate-Elicited Transcriptional Responses and Pentacyclic Triterpene Biosynthesis in Sweet Basil

Contact Info

Product

Resources

About