Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma

Abstract

Abstract. Decreased expression of human chemokine-like factor-like MARVEL transmembrane domain-containing 3 (CMTM3) has been identified in a number of human tumors and tumor cell lines, including gastric and testicular cancer, and PC3, CAL27 and Tca-83 cell lines. However, the association between CMTM3 expression and the clinicopathological features and prognosis of esophageal squamous cell carcinoma (ESCC) patients remains unclear. The aim of the present study was to investigate the correlation between CMTM3 expression and clinicopathological parameters and prognosis in ESCC. CMTM3 mRNA and protein expression was analyzed in ESCC and paired non-tumor tissues by quantitative real-time polymerase chain reaction, western blotting and immunohistochemical analysis. The Kaplan-Meier method was used to plot survival curves and the Cox proportional hazards regression model was also used for univariate and multivariate survival analysis. The results revealed that CMTM3 mRNA and protein expression levels were lower in 82.5% (30/40) and 75% (30/40) of ESCC tissues, respectively, when compared with matched non-tumor tissues. Statistical analysis demonstrated that CMTM3 expression was significantly correlated with lymph node metastasis (P=0.002) and clinical stage (P<0.001) in ESCC tissues. Furthermore, the survival time of ESCC patients exhibiting low CMTM3 expression was significantly shorter than that of ESCC patients exhibiting high CMTM3 expression (P=0.01). In addition, Kaplan-Meier survival analysis revealed that the overall survival time of patients exhibiting low CMTM3 expression was significantly decreased compared with patients exhibiting high CMTM3 expression (P=0.010). Cox multivariate analysis indicated that CMTM3 protein expression was an independent prognostic predictor for ESCC after resection. This study indicated that CMTM3 expression is significantly decreased in ESCC tissues and CMTM3 protein expression in resected tumors may present an effective prognostic biomarker.

Expression and significance of RRBP1 in esophageal carcinoma

“…Esophageal carcinoma is one of the most common malignant tumors in China, which accounts for the sixth most common cause of cancer-related death in the world. 1 , 2 Surgical resection is the main treatment for esophageal cancer patients; however, the 5-year survival rate of esophageal cancer patients after surgery is still less than 25%. 3 , 4 Currently, the incidence of esophageal carcinoma is still increasing in China.…”

“… 3 , 4 Currently, the incidence of esophageal carcinoma is still increasing in China. 1 , 5 , 6 The early diagnosis of esophageal carcinoma is a tough challenge. 7 , 8 Thus, it would be meaningful to explore novel molecular biomarkers associated with the early diagnosis and prognosis of esophageal cancer.…”

Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer

“…Interestingly, the CMTM3 promoter differs from those of other CMTM family members due to its typical CpG island. CMTM3 is known to be involved in tumor suppression; however, the methylation of the CMTM3 promoter has been shown to suppress CMTM3 expression in various cancer types, such as gastric, male laryngeal, esophageal, breast, nasopharyngeal, and colon carcinomas (8,(34)(35)(36). In the study of Li et al, CMTM3 was demonstrated to trigger G2 cell-cycle arrest and apoptosis in a p53-independent manner, leading to inhibition of the proliferative and migratory abilities of testicular cancer cells (NCCIT) (37).…”

Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer

“…International Publisher has different biological functions in different tumors, although they collectively play a suppressive role. Many cancers of the digestive tract such as esophageal, gastric, and oral cancer involve CMTM3 in several different pathways [28][29][30][31][32][33], while, cancers of digestive glands, like hepatocellular carcinoma, are also associated with CMTM members [34,35]. Moreover, researches in genitourinary cancers indicate that CMTM3 and CMTM8 suppress tumor cell reproduction and migration [36][37][38][39][40].…”