Expression and significance of RRBP1 in esophageal carcinoma

Wang, Liang; Wang, Ming; Zhang, Mingyun; Li, Xingde; Zhu, Zhaowei; Wang, Haiyan

doi:10.2147/cmar.s158013

Cited by 17 publications

(27 citation statements)

References 27 publications

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“…Compared with patients with low RRBP1 expression, patients with high RRBP1 expression had shorter disease-specific survival. RRBP1 was also highly expressed in esophageal carcinoma tissues and was associated with T stage, lymph node metastasis, TNM stage and survival (8). Similar studies were performed in endometrial endometrioid adenocarcinoma and prostate cancer, and RRBP1 was recognized as a potential protein marker (6,7).…”

Section: Discussionsupporting

confidence: 59%

“…RRBP1 inhibition could cause ER stress and significantly reduce cell tumorigenicity (4) RRBP1 was reported to be overexpressed in lung, colorectal, endometrial and prostate cancer (4)(5)(6)(7). High RRBP1 expression could promote esophageal and colorectal cancer progression, and can be used to predict patient prognosis (5,8). However, to the best of our knowledge, the expression of RRBP1 in bladder cancer has not been previously reported.…”

Section: Introductionmentioning

confidence: 99%

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RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion

et al. 2020

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Ribosome-binding protein 1 (RRBP1) is a marker for colorectal, lung, esophageal and prostate cancer. However, the association between RRBP1 and bladder cancer is not completely understood. The present study aimed to evaluate the expression and function of RRBP1 in bladder cancer. The association between RRBP1 expression and clinicopathological characteristics, as well as the prognosis of bladder cancer was analyzed. RRBP1 expression was further analyzed in bladder cancer cell lines via reverse transcription-quantitative PCR and western blotting. RRBP1 knockdown was established using short hairpin RNAs to investigate the function of RRBP1 in T24 cells. Compared with healthy bladder tissue, RRBP1 expression levels were significantly upregulated in bladder cancer tissue. High RRBP1 expression was associated with tumor stage, lymph node metastasis and shorter overall survival time. RRBP1 protein was highly expressed in bladder cancer cell lines compared with normal SV-HUC-1 cells. Compared with the control group, RRBP1 knockdown inhibited T24 migration and invasion by downregulating the expression of CC chemokine receptor type 7 (CCR7) protein. In conclusion, the present study indicated that RRBP1 was associated with bladder cancer migration, invasion and prognosis, and CCR7 might serve a role in the process.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion

et al. 2020

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“…RRBP1 is localized in the rough endoplasmic reticulum (rER) and supposed to play a role in secretion of newly synthesized protein [19]. RRBP1 is reported to be over expressed in breast [20], lung [19], colorectal [21], esophageal [22], endometrial [23], prostate [24] and ovarian cancer [25] patient tissues. RRBP1 expression is associated with the disease progression and also envisaged as an unfavourable post-operative prognosis [21].…”

Section: Discussionmentioning

confidence: 99%

RRBP1 rewires cisplatin resistance in Oral Squamous Cell Carcinoma by regulating YAP-1

Shriwas

Arya

Mohanty

et al. 2020

Preprint

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30Cisplatin-based chemotherapy still remains as one of the primary treatment modalities for 31 OSCC. Several OSCC patients experience relapse owing to development of chemoresistance. To 32 identify key resistance triggering molecules, we performed global proteomic profiling of human 33 OSCC lines presenting with sensitive, early and late cisplatin resistance patterns. From the 34 proteomic profiling study, human RRBP1 was identified to be upregulated in both early and late 35 cisplatin-resistant cells with respect to the sensitive counterpart. Analysis of OSCC patient 36 sample indicates that RRBP1 expression is elevated in chemotherapy-non-responder tumors as 37 compared to chemotherapy-naïve tumors. Knocking out RRBP1 resulted in restoring cisplatin 38 mediated cell death in chemoresistant lines and patient derived cells (PDC). Mechanistically, 39 RRBP1 regulates YAP-1 to induce chemoresistance in OSCC. The chemoresistant PDC 40 xenograft data suggests that knock out of RRBP1 induces cisplatin mediated cell death and 41 facilitates a significant reduction of tumor burden. We also found Radezolid, a novel 42 oxazolidinone antibiotic represses the expression of RRBP1 and restores cisplatin-induced cell 43 death in chemoresistant OSCC. This unique combinatorial approach needs further clinical 44 investigation to target advanced OSCC. Here with for the first time, we uncover the novel role of 45 RRBP1 as potential modulator of cisplatin resistance in advanced OSCC.46 48 developing countries. OSCC is an aggressive form of HNSCC and is the most common cancer 49 among Indian males [1]. Approximately 80,000 new OSCC cases are reported annually with a 50 mortality of 46,000 individuals each year in India. The traditional treatment modalities for 51 advanced OSCC comprises of surgical removal of primary tumors followed by concomitant 52 adjuvant chemoradiotherapy [2]. In addition, neoadjuvant chemotherapy is frequently 53 recommended for surgically unresectable OSCC tumors that reduces tumor and provides more 54 surgical options. Despite having these solutions, the 5-year survival rate of advance tongue 55 OSCC is approximately 50%, indicating a possible resistance to currently available therapeutics. 56 Chemoresistance is one of the important factors for treatment failure in OSCC [3]. Cisplatin 57 alone or in combination with 5-fluorouracil and taxane/docetaxel (TPF) are generally used as 58 chemotherapy regimen for OSCC [4]. But due to chemoresistance development, patients 59 experience relapse which leads to continued tumor growth and metastasis. The chemoresistant 60properties could be attributed to enhanced cancer stem cell population, decreased drug 61 accumulation, reduced drug-target interaction, reduced apoptotic response and enhanced 62 autophagic activities [5]. These hallmarks present the endpoint events, when cancer cell had 63 already acquired chemoresistance. Till date, the causative factors responsible for acquiring 64 chemoresistance in cells are yet not explored. Identifying these molecular triggers ...

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“…(10) In addition, we also found that RRBP1 is overexpressed in a variety of tumor cells, including liver cancer, prostate cancer, colorectal cancer, lung cancer, Her-2 (+) breast cancer, esophageal cancer, endometrial cancer and ovarian cancer. (10)(11)(12)(13)(14)(15)(16)(17) However, to date, few has explored the relationship between RRBP1 overexpression and the prognosis of cervical squamous cell carcinoma. The purpose of the present study was to investigate whether RRBP1 was overexpressed in cervical squamous cell carcinoma through immunohistochemistry, Western blotting and qRT-PCR.…”

Section: Introductionmentioning

confidence: 99%

“…According to a large number of previous studies, it was found that RRBP1 may interact with kinesin family member 5B (KIF5B) to participate in the accumulation of autophagosomes in tumor cells, and overexpression of RRBP1 causes ER stress to be alleviated and stabilized, leads to the accumulation of unfolded and folded proteins (UPR) in the endoplasmic reticulum, resulting in abnormal protein function, which can lead to cancer (18). Recently, overexpression of rrbp1 was found in liver cancer, prostate cancer, colorectal cancer, lung cancer, Her-2 (+) breast cancer, esophageal cancer, in endometrial cancer and in ovarian cancer and was closely associated with poor prognosis (9,10,(12)(13)(14)(15)(16)(17). …”

mentioning

confidence: 99%

Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma

Zhu

Zhao

et al. 2020

Preprint

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Purpose: The aim of this study was to investigate the relationship between endoplasmic reticulum ribosomal binding protein 1 (RRBP1) expression in cervical squamous cell carcinoma tissues and its poor prognosis. RRBP1 is a nascent transporter on the rough endoplasmic reticulum. Its function is to regulate the transport and secretion of proteins in cells, and to relieve endoplasmic reticulum (ER) stress, thereby promoting tumor cell proliferation.Methods: The expression levels of RRBP1 in 96 cervical squamous cell carcinoma tissues were detected by immunohistochemistry. Western blot and qRT-PCR were used to compare the expression levels of RRBP1 in cervical squamous cell carcinoma tissues and normal cervical tissues. Then the chi-square test was used to analyze the results of immunohistochemistry. Finally, the Kaplan-Meier method was used to analyze the results by log-rank test and Cox regression (proportional risk model).Result: The overexpression of RRBP1 in cervical squamous cell carcinoma tissues was related to FIGO stage (P=0.030), tissue differentiation (P=0.047), lymph node metastasis (P=0.031), and was not related to the patient age (P=0.667). Univariate survival analysis showed that the prognosis was associated to the expression level of RRBP1 (P=0.045) and lymph node metastasis (P=0.001). Analysis of multi-factor survival cox model proved that RRBP1 was an independent prognostic factor. Conclusion: RRBP1 was overexpressed in cervical squamous cell carcinoma tissues, indicating that RRBP1 may be a new tumor marker for early diagnosis, treatment and prognosis of cervical squamous cell carcinoma, and it will provide help for individualized treatment and prognosis of cervical squamous cell carcinoma in the future.

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Expression and significance of RRBP1 in esophageal carcinoma

Cited by 17 publications

References 27 publications

RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion

RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion

RRBP1 rewires cisplatin resistance in Oral Squamous Cell Carcinoma by regulating YAP-1

Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma

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