Chemoenzymatic synthesis of (S)-Pindolol using lipases

Lima, Gledson Vieira; Silva, Marcos Reinaldo da; Fonseca, Thiago de Sousa; Lima, Leandro B.; Oliveira, Maria da Conceição Ferreira de; Lemos, Telma L. G.; Zampieri, Dávila; Santos, José Cleiton Sousa dos; Rios, Nathália Saraiva; Gonçalves, Luciana Rocha Barros; Molinari, Francesco; Mattos, Marcos Carlos de

doi:10.1016/j.apcata.2017.08.003

Cited by 110 publications

(35 citation statements)

References 46 publications

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“…However, there are other possible derived applications such as air filtration and drug delivery 28,29 . In fact, nowadays, similar structures are used for nanotechnology applications, for example, catalysis 30–34 . Another application in which elastin could be of great interest is in the immobilization and absorption of enzymes 35–37 .…”

Section: Introductionmentioning

confidence: 99%

Influence of elastin on the properties of hybrid PCL/elastin scaffolds for tissue engineering

Sánchez‐Cid

Perez‐Puyana

Jiménez‐Rosado

et al. 2021

J of Applied Polymer Sci

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Developing scaffolds by combining different polymers in order to improve the properties of the bare polymers has become an extensively applied practice. Polycaprolactone (PCL) is a synthetic polyester with outstanding properties for tissue engineering (TE), although it does have certain drawbacks that can be counteracted by combining it with other biopolymers. The biopolymer elastin is an essential functional component of the dermal extracellular matrix. Therefore, the aim of this work was to produce binary systems comprising a combination of PCL (16 wt/vol%) and different concentrations of elastin (2 and 4 wt/vol%) to evaluate how the protein affects the matrix. To this end, the morphological, physicochemical, mechanical and biological properties of the aforementioned scaffolds were further characterized, observing that PCL/elastin is a suitable mixture as it improves the wettability of PCL when combined with elastin (the contact angles were reduced from 102 to ca. 70°). In addition, mixing PCL with a small quantity of elastin (2%) improved the mechanical properties of PCL‐based scaffolds (Young's modulus increased from 36 to 69 MPa and the maximum stress increased from 11 to 34 MPa).

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Section: Introductionmentioning

confidence: 99%

Influence of elastin on the properties of hybrid PCL/elastin scaffolds for tissue engineering

Sánchez‐Cid

Perez‐Puyana

Jiménez‐Rosado

et al. 2021

J of Applied Polymer Sci

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“…According to the modes of interaction between enzymes and supports, immobilization methods can be classified into physical or chemical methods, as shown in the scheme in Figure 5 [180,218]. Physical methods show weaker monovalent interactions, such as hydrogen bonds, hydrophobic interactions, van der Waals forces, affinity or ionic bonding of enzymes to the support, or the mechanical containment of enzymes within the support [219][220][221][222]. In chemical methods, the formation of covalent bonds occurs from ether, thioether, amide, or carbamate bonds between the enzyme and According to the modes of interaction between enzymes and supports, immobilization methods can be classified into physical or chemical methods, as shown in the scheme in Figure 5 [180,218].…”

Section: Enzyme Immobilizationmentioning

confidence: 99%

Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications

et al. 2021

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Among the many biological entities employed in the development of biosensors, enzymes have attracted the most attention. Nanotechnology has been fostering excellent prospects in the development of enzymatic biosensors, since enzyme immobilization onto conductive nanostructures can improve characteristics that are crucial in biosensor transduction, such as surface-to-volume ratio, signal response, selectivity, sensitivity, conductivity, and biocatalytic activity, among others. These and other advantages of nanomaterial-based enzymatic biosensors are discussed in this work via the compilation of several reports on their applications in different industrial segments. To provide detailed insights into the state of the art of this technology, all the relevant concepts around the topic are discussed, including the properties of enzymes, the mechanisms involved in their immobilization, and the application of different enzyme-derived biosensors and nanomaterials. Finally, there is a discussion around the pressing challenges in this technology, which will be useful for guiding the development of future research in the area.

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“…Enantiomeric excess (e.e. ), conversion (c) and enantioselectivity (E = enantiomeric ratio [26] of the LMKR were calculated as previously reported [27], using the following equations.…”

Section: Calculation Of Enantiomeric Excess Conversion and Enantiosementioning

confidence: 99%

“…Despite of this, higher enzyme flexibility is normally observed in hydrolysis performed in aqueous media (without co-solvent), where water molecules induce conformational changes in the active site [28][29][30]. It is suggested that addition of a co-solvent capable of stripping off water molecules from the enzyme active site changes its microenvironment, inducing changes in the enzyme conformation [27]. Besides promoting changes in enzyme conformation, addition of a co-solvent to the reaction aqueous system also influences the mass-transfer of substrate between the aqueous and organic phases due to the presence of an interface.…”

Section: Lmkr Of Rac-4-acmentioning

confidence: 99%

Lipase-catalysed enantioselective kinetic resolution of rac-lipidic alkynylcarbinols and a C5 synthon thereof via a hydrolysis approach

Almeida

Silva

Mattos

et al. 2020

Molecular Catalysis

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Chemoenzymatic synthesis of (S)-Pindolol using lipases

Cited by 110 publications

References 46 publications

Influence of elastin on the properties of hybrid PCL/elastin scaffolds for tissue engineering

Influence of elastin on the properties of hybrid PCL/elastin scaffolds for tissue engineering

Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications

Lipase-catalysed enantioselective kinetic resolution of rac-lipidic alkynylcarbinols and a C5 synthon thereof via a hydrolysis approach

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