Chemodectomas of the Middle Ear: A Comparison of Therapeutic Modalities

Gr, Moore; Jp, Robbins; Dl, Seale; Gs, Fitz-Hugh; Wc, Constable

doi:10.1001/archotol.1973.00780020342013

Cited by 26 publications

(7 citation statements)

References 27 publications

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“…10,15,20 Technological advances in the past 50 years have increased the prominence of multimodality, multispecialty treatment. 3,5,8,10,11,15,21,22 Debate surrounds the best treatment course, and many practitioners find themselves reevaluating what treatment will yield the ideal results for their patients. Evidence increasingly points toward excellent outcomes with both neurosurgical and radiosurgical techniques-but which is superior?…”

Section: Discussionmentioning

confidence: 99%

Comparative Neurologic Outcomes of Salvage and Definitive Gamma Knife Radiosurgery for Glomus Jugulare: A 20-Year Experience

et al. 2017

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This case series investigates management of glomus jugulare (GJ) tumors utilizing definitive and salvage Gamma Knife stereotactic radiosurgery (GKSRS). A retrospective chart review was performed to collect data. Statistical analysis included patient, tumor, and treatment information. From 1996 to 2013, 17 patients with GJ received GKSRS. Median age was 64 years (range, 27-76). GKSRS was delivered for definitive treatment in eight (47%) and salvage in nine (53%) patients. Median tumor volume was 9.8 cm (range, 2.8-42 cm ). Median dose was 15 Gy (range, 13-18 Gy). Median follow-up was 123 months (range, 38-238 months). Tumor size decreased in 10 (59%), stabilized in 6 (35%), and increased in 1 patient (6%). Overall neurological deficit improved in 53%, stabilized in 41%, and worsened in 6% of patients. Overall cause-specific survival was 100%, and actuarial local control was 94%. Eighty-eight percent of patients without prior resection experienced neurologic deficit improvement, while 25% of patients with prior resection experienced neurologic improvement ( = 0.02). Gamma Knife radiosurgery provides effective long-term control of GJ and overall improvement or stabilization of neurological deficit in most patients. Patients with prior resection are less likely to experience improvement of neurologic deficit.

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Section: Discussionmentioning

confidence: 99%

Comparative Neurologic Outcomes of Salvage and Definitive Gamma Knife Radiosurgery for Glomus Jugulare: A 20-Year Experience

et al. 2017

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“…Two studies in particular highlight the idea of appropriately size-specific management paradigms. 45,46…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors

Ivan

Sughrue²,

Clark³

et al. 2011

JNS

119

111

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The authors' analysis is limited by the quality and accuracy of these studies and may reflect source study biases, as it is impossible to control for the quality of the data reported in the literature. Finally, due to the diverse range of data presentation, the authors found that they were limited in their ability to study and control for certain variables. Some of these limitations should be minimized with their use of meta-analysis methods, which statistically evaluate and adjust for between-study heterogeneity. These results provide the impetus to initiate a prospective study, appropriately controlling for variables that can confound the retrospective analyses that largely comprise the existing literature.

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“…Others view radiotherapy as the initial treatment 5,9,11 due to the morbidity of surgical procedure. The objective is to have local/regional control of the disease in the long term, without any subjective our objective progression of the disease.…”

Section: Discussionmentioning

confidence: 99%

Tratamento radioterápico dos tumores glômicos do osso temporal

Dall’Igna

Antunes²,

Dall'Igna

2005

Rev. Bras. Otorrinolaringol.

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The treatment of glomic tumors has been controversial since its first description. It can be done with surgery, radiotherapy or just expectation. Aim: The objective of this paper was to evaluate the effectiveness and complications of radiotherapy. Study design: clinical with transversal cohort. Material and Method: It was made a retrospective review in the charts of the patients with glomus jugulare tumors treated with radiotherapy. Disease control was determined by (1) no progression of symptoms or cranial nerve dysfunction or (2) no progression of the lesion in radiological follow-up. It was also evaluated the follow-up period and the sequelae of the treatment. Results: Twelve patients were included, 8 of then women. The follow-up period was from 3 to 35 years, with a media of 11,6 years. The main symptoms were: hearing loss, pulsate tinnitus, dizziness and vertigo. The signs were pulsate retrotympanic mass, facial palsy and cofosis. The tumors were staged using Fisch's classification. The radiotherapy was performed with linear accelerator with dose ranging from 4500-5500 in 4-6 weeks. In the follow-up period were possible to identify sequelaes like dermatitis, meatal stenosis, cofosis and facial palsy. Discussion: The signs and symptoms were the same found in the medical literature. The type and dosages of the radiotherapy were also the same of others reports. All patients had improvement of the symptoms and only one was not considered as having disease controlled. Complications were, in general, minor complications, with exception of the cofosis and facial palsy. Conclusion: Radiotherapy is a viable alternative to treatment of these tumors because their good response and low level of complications. It should be considered specially in advanced tumors where a surgical procedure could bring a high level of morbidity.

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Chemodectomas of the Middle Ear: A Comparison of Therapeutic Modalities

Cited by 26 publications

References 27 publications

Comparative Neurologic Outcomes of Salvage and Definitive Gamma Knife Radiosurgery for Glomus Jugulare: A 20-Year Experience

Comparative Neurologic Outcomes of Salvage and Definitive Gamma Knife Radiosurgery for Glomus Jugulare: A 20-Year Experience

A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors

Tratamento radioterápico dos tumores glômicos do osso temporal

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