Chemo preventive potential of fruit juice of Phyllanthus emblica Linn. (amla) against mammary cancer by altering oxidant/antioxidant status, lipid profile levels and estrogen/progesterone receptor status in female Sprague–Dawley rats

Vaithiyanathan, Veluchamy; Mirunalini, Sankaran

doi:10.1016/j.bionut.2013.10.005

Cited by 7 publications

(3 citation statements)

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“…The chemoprotective potential of naturally occurring phytochemicals in food or medicinal plants continues to be a major area of scientific interest . It is generally accepted that the consumption of fruits and vegetables may reduce the risk of human cancers . Plants and plant products have long been used in medicine especially by nonindustrialized societies .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

Vaithiyanathan

Mirunalini

2015

Oral Science International

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a b s t r a c tBackground: Oral cancer is the sixth most common malignancy worldwide and is thus an important cause of death and morbidity. Although several drugs have been developed for the treatment of oral cancer, naturally occurring phytochemicals have been recommended by nutritionists and health experts to treat various types of cancer. Pergularia daemia is a well-known herb distributed across India, finding many uses in medicine. Aim: The present study was mainly designed to determine the dose-response effect of the whole plant extract of P. daemia on experimental oral carcinogenesis. Materials and methods: Male golden Syrian hamsters were painted with 0.5% of 7,12dimethylbenz[a]anthracene (DMBA) in liquid paraffin on the left buccal pouch to induce oral cancer, thrice a week for 14 weeks. The anticancer effect of the ethyl acetate and methanolic extracts of P. daemia was observed to be dose dependent (100, 200, and 300 mg/kg body weight (bwt)) by assessing the bwt, tumor incidence, changes in oxidant/antioxidant levels, and histological alterations of control and experimental animals. Results: Our results showed that of the three doses used, the high dose (300 mg/kg bwt) exhibited excellent antioxidant activity in comparison to the other two doses. Moreover, our findings suggest that the methanolic extract significantly inhibited cancer development to a greater extent than the ethyl acetate extract. Conclusion: Thus, it could be concluded that the whole plant of P. daemia presents an easily accessible source of natural antioxidants, and regular consumption can reduce the incidence of oral cancer.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

Vaithiyanathan

Mirunalini

2015

Oral Science International

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“… 3 Different phytochemicals of PEL extract are reported to possess desirable cytotoxicity against tumor cells and reverse the status of antioxidants to normal level in cancer-bearing animals. 14 , 15 They not only supplement the conventional treatment that can act at almost each step of carcinogenesis but offer better conditions with minor side effects. 5 , 13 In the present study, we explored the primary chemical components, tannins, organic acids, and flavonoids by implementing LC/MS/MS analysis.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Effects ofPhyllanthus emblicaL on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway

et al. 2016

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Background. Phyllanthus emblica L (PEL), a well-known medical plant, has been used in Asian countries for a long time. Increasing evidence suggests that it can prevent the tumorigenesis of cancer associated with nonresolving inflammation. However, the possible anti-inflammatory mechanism responsible for preventing tumorigenesis of precancerous lung lesions is not well elucidated. Materials and methods. Male A/J mice were randomly divided into 5 groups with 10 mice in each group: (1) blank group (saline), (2) benzo(a)pyrene [B(a)P] group, (3) and (4) B(a)P + PEL (5 g/kg/d, 10 g/kg/d, administered by gavage), (5) B(a)P + celecoxib (30 mg/kg/d, administered by gavage). Nodes on the lung surface were observed and calculated. The levels of macrophage inflammatory protein (MIP-2), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β were detected by enzyme-linked immunosorbent assay (ELISA) kits. Cyclo-oxygenase-2 (COX-2), hypoxia-inducible factor-1 (HIF-α), IL-1β, miR-101, and Lin28B protein levels were evaluated by immunohistochemistry and Western blotting. Results. PEL extract treatment significantly reduced the number of nodes on the lung surface and attenuated B(a)P-induced levels of proinflammatory cytokines MIP-2, TNF-α, IL-6, and IL-1β in lung tissue. The protein expressions of COX-2 and HIF-α were significantly decreased by the treatment of PEL. In addition, both PEL extract and celecoxib markedly upregulate the expression of miR-101 while downregulating IL-1β and Lin28B levels. Conclusion. Our study indicated that treatment with PEL extract can not only protect the lung from inflammatory injury but effectively prevent precancerous lung lesions through regulating the IL-1β/miR-i101/Lin28B signaling pathway.

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“…[ 2 ] Antioxidants are nutritional substances which could prevent or slow down the oxidative damage and act as free radical scavengers, preventing and repairing cellular and molecular damage. [ 3 ] In recent years, much attention has been devoted to natural antioxidant and their association with health benefits. Numerous ethnopharmacological surveys were conducted and revealed that large numbers of lactiferous plant species are used as a source of herbal therapies.…”

Section: Introductionmentioning

confidence: 99%

Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

Vaithiyanathan

Mirunalini

2015

Toxicol Int

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Background:Pergularia daemia (Asclepiadacea) is a fetid- smelling perennial herb growing well along the river bang and road sides of India. Naturally the plant has powerful antioxidants including polyphenols, flavanoids, steroids and terpenoids.Objective:The aim of this study is to evaluate the in vitro antioxidant potential and to determine the median lethal dose (LD50) of crude ethyl acetate and methanol extracts of Pergularia daemia. The plant Pergularia daemia possess effective scavenging activity against 2, 2' azino bis (3 ethylbenzothiazoline 6 sulfonic acid (ABTS), nitric oxide and reducing power radicals at different concentrations (100, 200, 300, 400 & 500 µg/mL) of both extracts.Results:From the above in vitro assay we have exposed that the methanolic extract exert higher antioxidant activity at 400 µg/mL than ethyl acetate extract. Acute toxicity study revealed that the extracts showed no signs of toxicity upto a dose level of 2500 mg/kg b.wt.Conclusion:Thus our findings provide that both extracts of Pergularia daemia possess a strong antioxidant capacity and are relatively has high margin of safety.

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Chemo preventive potential of fruit juice of Phyllanthus emblica Linn. (amla) against mammary cancer by altering oxidant/antioxidant status, lipid profile levels and estrogen/progesterone receptor status in female Sprague–Dawley rats

Cited by 7 publications

References 44 publications

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

Anti-inflammatory Effects ofPhyllanthus emblicaL on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway

Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

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