Chemo‐ and Regioselective Synthesis of Arylated γ‐Valerolactones from Bio‐based Levulinic Acid with Aromatics Using H‐β Zeolite Catalyst

Abstract

Catalytic coupling of biomass-based molecules to value-added chemical intermediates is an interesting area in biomass research. Arylated γ-valerolactones (Agvls), promising pharmaceutical intermediates that have significant biological activity, are primarily synthesized currently through petro-route. In this paper, we report successful biomass-based synthesis of Agvls using levulinic acid (LA) and oxygen or sulphur-substituted aromatics over H-β zeolite as catalyst under solvent-free conditions. Under optimized condition, LA and anisole render 90 % conversion of former with 82 % yield of para-substituted γlactone. CÀ C bond formation followed by intra-molecular esterification is witnessed in the course of the reaction, which is highly chemo-and regioselective. Though catalyst deactivated while reuse due to deposition of organic carbon moieties as deduced from several physicochemical techniques, it could be regenerated by simple calcination.[a] Dr.

Catalytic Conversion of Levulinic Acid into 2-Methyltetrahydrofuran: A Review

“…These reactions include hydrocyclization, hydrogenation, dehydration, oxidation, reductive amination, halogenation, alkylation, and condensation, as illustrated in Scheme 3 . LA can act as an intermediate in the synthesis of many compounds, including arylated cyclic lactones, alkylated lactones, ketals, halo substituted keto carboxylic acids, amides (cyclic/acyclic), valerates, valeric acids, aliphatic alcohols, acid halides, 1,4-diketones, alkanes, alkenes, cyclic ethers, and numerous other derivatives [ 24 , 25 , 26 , 27 ]. LA contains oxygen functionality (oxo and carboxylic), leading to the production of numerous high-value products through hydrocyclization and hydrodeoxygenation reactions [ 28 ].…”

Recent Catalytic Approaches for the Production of Cycloalkane Intermediates from Lignin‐Based Aromatic Compounds: A Review

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