Chemistry of immunomodulators

Lefrancier, P.

doi:10.1016/0147-9571(85)90043-8

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…In the last years a number of substances have been discovered, such as synthetic products, inorganic compounds, substances of natural origin capable of acting on the immune response, specific or aspecific [11]. On the ground of these researches new therapies have been suggested in order to modify, stimulate or weaken the immune response, according to the needs.…”

Section: Discussionmentioning

confidence: 99%

Clinical results obtained in cattle and swine by means of biological immunostimulators1

Galassi

Galassi²,

Pelliccioni

et al. 1986

Comparative Immunology, Microbiology and Infectious Diseases

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The conditioned infections due to opportunistic organisms, can be controlled by biological immunostimulators. The POLI-IF (Newcastle virus plus endotoxin of E. coli and Freund's incomplete adjuvant) rapidly induces the aspecific immunity. Given twice with 7-10 days interval in between, on occasion of a programmed stress (weaning, transport, crowding) it proved its efficacy in artificially suckled calves and in weaning piglets. The field trials, carried out on 2,782 treated calves in comparison with 2,909 untreated controls and on 4,387 piglets in comparison with 4,461 untreated controls, revealed statistically significant differences for P less than 0.005 among the groups of treated and control animals. The immunostimulator reduced the incidence of the disease, dead and discarded animals, as well as it shortened the mean duration of the disease in single heads. Though the way the POLI-IF acts is not perfectly known so far, yet it increases the serum bactericidal activity and the circulating leukocytes, while it induces high levels of IFN. In our opinion the activity of the POLI-IF is bound to 3 factors at least: activation of the complementary fractions, mobilization of the immunocompetent cells, induction of IFN.

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Section: Discussionmentioning

confidence: 99%

Clinical results obtained in cattle and swine by means of biological immunostimulators1

Galassi

Galassi²,

Pelliccioni

et al. 1986

Comparative Immunology, Microbiology and Infectious Diseases

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“…Streptomyces calvus ABRIINW673 strain (isolated from a soil sample collected in Hamedan, Iran) was obtained from the bacterial culture collections of the Department of Microbial Biotechnology, AREEO, Tabriz, Iran [14]. It was grown on a Mueller Hinton agar medium.…”

Section: Preparation Of Bacterial Samplementioning

confidence: 99%

“…Secondary metabolites are organic compounds that are not directly associated with the normal growth, development or propagation of a microorganism, unlike primary metabolites that are essential for the growth of microorganisms. Streptomyces bacteria are ubiquitous in soil and they have an important ecological role in the turnover of organic materials [14]. One member of this genus, which is known for its fluorinated compounds, is Streptomyces calvus.…”

Section: Introductionmentioning

confidence: 99%

The immunomodulatory activity of secondary metabolites isolated fromStreptomyces calvuson human peripheral blood mononuclear cells

Mahmoudi

Baradaran

Dehnad

et al. 2016

British Journal of Biomedical Science

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Immunotherapies inducing immunogenic cell death in cancer: insight of the innate immune system

Calvillo-Rodríguez,

Lorenzo-Anota,

Rodríguez-Padilla

et al. 2023

Front. Immunol.

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Cancer immunotherapies include monoclonal antibodies, cytokines, oncolytic viruses, cellular therapies, and other biological and synthetic immunomodulators. These are traditionally studied for their effect on the immune system’s role in eliminating cancer cells. However, some of these therapies have the unique ability to directly induce cytotoxicity in cancer cells by inducing immunogenic cell death (ICD). Unlike general immune stimulation, ICD triggers specific therapy-induced cell death pathways, based on the release of damage-associated molecular patterns (DAMPs) from dying tumour cells. These activate innate pattern recognition receptors (PRRs) and subsequent adaptive immune responses, offering the promise of sustained anticancer drug efficacy and durable antitumour immune memory. Exploring how onco-immunotherapies can trigger ICD, enhances our understanding of their mechanisms and potential for combination strategies. This review explores the complexities of these immunotherapeutic approaches that induce ICD, highlighting their implications for the innate immune system, addressing challenges in cancer treatment, and emphasising the pivotal role of ICD in contemporary cancer research.

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Chemistry of immunomodulators

Cited by 3 publications

References 26 publications

Clinical results obtained in cattle and swine by means of biological immunostimulators1

Clinical results obtained in cattle and swine by means of biological immunostimulators1

The immunomodulatory activity of secondary metabolites isolated fromStreptomyces calvuson human peripheral blood mononuclear cells

Immunotherapies inducing immunogenic cell death in cancer: insight of the innate immune system

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