Chemistry of 3-azabicyclo[3.3.1]nonanes

Crystal structure of 2,6‐diphenyl azabicyclo [3.3.1] nonan‐9‐one thiosemicarbazone

“…The title compound (CCDC 206345) was prepared by Mannich condensation reaction using two mole of benzaldehyde, one mole of ammonium acetate and one mole of cyclohexanone [2:1:1] and heated on a hot plate up to the boiling range [18,19]. The reacting product 2,6-diphenyl [3.3.1] azabicyclo-9-one was obtained.…”

Synthesis, Biological Evaluation and Docking Studies of some Novel (E)-(4-(2-(Benzo[d]Thiazol-2-yl)Hydrazono)Methyl-2,6-Diphenylpiperidin-1-yl)(Phenyl)Methanone Derivatives

“…Nitrogen containing heterocycles always signified a subject of great interest due to their ubiquity in nature and massive presence as part of the skeletal backbone of many therapeutic agents [1]. Piperidin-4-one nucleus are interested to study because of their broad spectrum of biological activities such as antibacterial and antifungal [2][3] local anesthetic [4] antiviral [5] antitumor [6].…”

Synthesis and antimicrobial studies of novel 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one 4′-phenylthiosemicarbazones

“…Jeyaraman and Avila [16] have reviewed the importance of bicyclic compounds as intermediates in the synthesis of a several physiologically active compounds. Similarly, Lijinsky and Taylor [17] have found that the presence of substituents at both the α-positions to that of "N" in piperidin-4-one is important to exert marked biological properties.…”