Chemistry of 2-Amino-3-cyanopyridines

Synthesis of Some Novel 4‐(Furan‐2‐yl)‐5,6‐dimethylpyridines

“…This is much desired by chemists because avoiding a lengthy separation process and purification of the intermediate chemical compounds would save time and resources while increasing chemical yield. An example of a one‐pot synthesis is the 2‐amino‐4‐(substituted) nicotinonitrile . In view of these facts and as a continuation of our research program on the chemistry of nicotinonitrile and furan , the present investigation aimed to synthesize and characterize newer nicotinonitrile incorporating furan moiety.…”

Green synthesis, molecular docking and pharmacological evaluation of new triazolo‐thiadiazepinylcoumarine derivatives as sedative‐hypnotic scaffold

“…Our study has been expanded to the reaction of 1 with a variety of α,β‐unsaturated carbonitrile derivatives 9a‐g in order to synthesize new compounds having an o‐aminocyano or o‐aminoester moiety, which can be used as starting materials for synthesis of other fused heterocycles . Thus, reaction of compound 1 with 2‐arylidenemalononitriles 9a‐d , or ethyl 2‐cyano‐3‐arylacrylates 9e‐g to afford compounds 12a‐d and 12e‐g , respectively (Scheme )…”

Synthesis of new pyridines with sulfonamide moietyviaa cooperative vinylogous anomeric-based oxidation mechanism in the presence of a novel quinoline-based dendrimer-like ionic liquid

“…[30][31][32][33][34] Therefore, pyridine and its derivatives (particularly 2-aminonicotinonitrile) have received extensive consideration and several efficacious methods have been developed by synthetic and medicinal chemists for their preparation. [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] So, it is predicted that multicomponent synthesis [52][53][54][55][56] of a single molecule bearing sulfonamide and pyridine centers simultaneously gives unique features to that structure inherited characteristics of both cores.…”