Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic fungus Phomopsis sp. ZSU-H76

Antimicrobial activity of crude extracts from mangrove fungal endophytes

“…Based on their morphology and LSU and ITS sequence analyses, our active mangrove endophytic fungal isolates can be classified into six genera, Acremonium, Diaporthe, Hypoxylon, Pestalotiopsis, Phomopsis, and Xylaria. The genera Diaporthe, Phomopsis, Pestalotiopsis and Xylaria have been reported to be the most common endophytes isolated from mangrove plants (Cheng et al 2008;Huang et al 2008;Pang et al 2008;Chareprasert et al 2010). Many mangrove endophytes have been reported to produce antimicrobial substances such as Colletotrichum sp., Xylaria sp., Pestalotiopsis sp., Paecilomyces sp., Phomopsis sp.…”

“…Endophytic fungi have been shown to produce a wide range of biologically active metabolites (Aly et al 2010). Natural products from mangrove fungal endophytes with biological activity have been reported (Chen et al 2007;Huang et al 2008). However antimicrobial activity from endophytic fungi isolated from mangroves in Thailand has been rarely studied.…”

Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108

“…More than 200 species of endophytic fungi have been isolated and identified from mangrove plants and several reports on the isolation of antibiotic compounds from endophytic fungi have been reported. To mention a few griseofulvin, [7], chaetomugilin A and D [8], cytosporone B and C [9], 3-O-methylalaternin and altersolanol A [10], phomoenamide [11], phomodione [12], ambuic acid [13], isopestacin [14], munumbicin A, B, C, and D [15], pestalachlorides A and B, [16], brefeldin A [17], coronamycin, [18], pumilacidin [19], cytochalasin D [20], polyketide citrinin [21,22], fumigaclavine C, fumitremorgin C, physcion [23], and several others.…”

Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4

“…ZSU H76 from the South China Sea. Cytosporone B and C inhibited the growth of two fungi Candida albicans and Fusarium oxysporum with an MIC ranging from 32 to 64 microg/mL [10] . The structure activity analysis of secondary metabolites of mangrove fungi indicated that the hydroxyl group was important for their cytotoxic activity and that bulky functional groups such as phenyl rings could result in a loss of biological activity, which will direct further development of marine product based derivatives [11] .…”