Chemistry and Metabolism of the Compounds of Phosphorus

Green, and A A; Colowick, Sidney P.

doi:10.1146/annurev.bi.13.070144.001103

Cited by 8 publications

(2 citation statements)

References 46 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this connection it is interesting to note that Mn and Mg ions have been shown to be essential for phosphatase activity (Green and Colowick, 1944), for the reaction between phosphopyruvate and adenosine diphosphate in cell-free bacterial suspensions (Boyer, Lardy, and Phillips, 1943), and for the oxidation of pyruvic acid in Lactobacillus delbrueckii (Lipmann, 1937) and Escherichia coli (Krebs, 1937). Also of possible interest is the recent work of Webb (1948), who has shown that Mg++ is required for the cell division mechanism of Clostridium welchii.…”

Section: ]mentioning

confidence: 99%

THE EFFECT OF IONIC Mn AND Mg ON THE VARIATION OF BRUCELLA ABORTUS

Cole¹,

Braun²

1950

J Bacteriol

View full text Add to dashboard Cite

Although the modifying effect of environmental factors on bacterial variation (dissociation) has been widely studied (Braun, 1947), there has been a paucity of data concerning the influence of the trace metals on this phenomenon. In the course of an investigation of factors that influence variation in Brucella abortu8, our attention was directed to the possible role of the trace metal ions by the finding that during prolonged growth of smooth cultures of B. abortus in broth no nonsmooth variants (e.g., R, M) could be observed when 0.03 M Na-pyrophosphate was added to the medium. In contrast, similar cultures without pyrophosphate showed a progressive establishment of nonsmooth variants (mutants). Since pyrophosphate forms complexes with many metal ions and is known to inhibit certain enzymes (Sumner and Somers, 1947), the present study was undertaken in an attempt to elucidate the mechanism of action of pyrophosphate as well as of trace enetals in bacterial variation. METHODS A description of the procedures employed in the study of variation (dissociation) in B. abortus has been published previously (Braun, 1946). The method is based on the determination of the dissociation index (D.I.)2 of a clone (2583) of B. abortus (originally isolated from strain 19, U. S. Bureau of Animal Industry), cultured in buffered beef extract broth (pH 6.8) under standardized

show abstract

Section: ]mentioning

confidence: 99%

THE EFFECT OF IONIC Mn AND Mg ON THE VARIATION OF BRUCELLA ABORTUS

Cole¹,

Braun²

1950

J Bacteriol

View full text Add to dashboard Cite

show abstract

“…These metabolic inhibitors are known to interfere with hydrogen transport (Stannard and Horecker, 1948) and/or phosphorylation (Reiner and Spiegelman, 1947). Because "high energy phosphate" ( ^P) is equilibrated with the adenosine triphosphate (ATP) within the cell (Green and Colowick, 1944), it was considered possible that the inhibition of cleavage, produced by the above agents, might be reversed by addition of ATP.…”

mentioning

confidence: 99%

Cell Division Inhibition of Arbacia and Chaetopterus Eggs and Its Reversal by Krebs Cycle Intermediates and Certain Phosphate Compounds ,

Barnett

1953

The Biological Bulletin

View full text Add to dashboard Cite

273fered with (azide and DNP), ATP atone cannot make up the deficit. The fact that malonate is able completely to inhibit division of Arbacia and Chaetopterus eggs, and succinate and fumarate are able completely to reverse this inhibition, is strong evidence that division is intimately dependent upon a functioning Krebs cycle. Further, because ATP was unable to reverse completely the division inhibition clue to the action of malonate, the function of the Krebs cycle in division may not be completely accounted for on the basis of ' P generation. SUMMARY Division of Arbacia eggs was inhibited by low oxygen tension, cyanide, azide, dinitrophenol (DXP) and malonate. Various high and low r energy phosphate compounds, and succinate and fumarate were added to the inhibited eggs. The results were extended to malonate-inhibited Chaetopterus eggs and the effects of succinate and fumarate were noted.

show abstract

A histochemical and quantitative study of phosphatase in the placenta and fetal membranes of the guinea pig

Hard

1946

Am. J. Anat.

View full text Add to dashboard Cite

Chemistry and Metabolism of the Compounds of Phosphorus

Cited by 8 publications

References 46 publications

THE EFFECT OF IONIC Mn AND Mg ON THE VARIATION OF BRUCELLA ABORTUS

THE EFFECT OF IONIC Mn AND Mg ON THE VARIATION OF BRUCELLA ABORTUS

Cell Division Inhibition of Arbacia and Chaetopterus Eggs and Its Reversal by Krebs Cycle Intermediates and Certain Phosphate Compounds ,

A histochemical and quantitative study of phosphatase in the placenta and fetal membranes of the guinea pig

Contact Info

Product

Resources

About