Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources

Abstract

Natural products containing non-tetramic gamma-hydroxy-gamma-lactams and gamma-alkylidene-gamma-lactams are usually but not exclusively derived from the mixed polyketide-non-ribosomal peptide biosynthetic pathway. Often they are fungal metabolites, although some plant- and marine-derived exceptions exist. Owing to their unique structures and biological properties, they have gained interest in the chemical and biological communities. In this review, we aim to emphasize the structural originality of these compounds, their biological properties and the synthetic efforts developed to reach them; 157 references are cited.

Antimicrobial Strategies Effective Against Infectious Bacterial Biofilms

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Methylene Blue as a Photosensitizer and Redox Agent: Synthesis of 5‐Hydroxy‐1H‐pyrrol‐2(5H)‐ones from Furans

“…Thet argets of this methodology were carefully chosen, since 5-hydroxy-1H-pyrrol-2(5H)-ones 3 are highly important heterocyclic motifs.N ot only do they exist in al arge number of natural products, [7] but they also exhibit significant biological activity. Thet argets of this methodology were carefully chosen, since 5-hydroxy-1H-pyrrol-2(5H)-ones 3 are highly important heterocyclic motifs.N ot only do they exist in al arge number of natural products, [7] but they also exhibit significant biological activity.…”

N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis

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