ChemInform Abstract: Triazines as Anti‐Inflammatory Agents.

Abstract

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Attenuation of NF-κB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis

“…To further examine the involvement of the signaling pathway, we focused first on NF-jB, as there was a report of anti inflammatory effect of 5a [9]. Indeed, the link between oxidative stress and NF-jB was established mainly from the inhibition of NF-jB activation by cellular antioxidants [37][38][39][40].…”

“…Briefly, a mixture of compound 1 and sodium cyanide was refluxed in alcohol for 2 h. 1,2-bis(4-methoxyphenyl)ethandione (3) was prepared according to the known method of preparation of benzyl [13]. The treatment of 1,2-bis(4-methoxyphenyl)ethandione with thiosemicarbazide, according to the previously described procedure [9], resulted in 1,2,4-triazine ring closure and provided 5,6-diaryl-1,2,4-triazine-3-thiol (4). This key intermediate was separately reacted with three alkyliodides (methyliodide, ethyliodide and n-propyliodide), in the presence of triethylamine in methanol, to give compounds 5a-c, respectively.…”

“…Many investigations revealed the anticancer potential of various types of triazine derivatives [8]. Some of the others have been introduced as anti inflammatory [9], radical scavenger [10], and b-sheet breaker [11] agents. 3-(methylthio)-5,6-di-(4-methoxyphenyl)-1,2,4-triazine is one of the thioalkyl 5,6-diphenyl triazine derivatives that its antiinflammatory action has been determined by Saxena et al [9].…”

Facile and one pot synthetic routes for various novel, differently fused and promising heteropolycycles

“…The quinazoline ring system is a commonly encountered structural core in a number of natural and synthetic molecules with a wide range of biological activities [13]. Many of the quinazoline derivatives are known to exhibit anti-inflammatory [14], anthelmentic [15], analgesic [16], CNS-depressant [17], and anticonvulsive activities [18]. Metolazone and quinethazone are two quinazoline-based drugs that are used currently as diuretics in medicines [19].…”

Simple and efficient synthetic routes to bioactive s-triazinyl dithiocarbamate derivatives

“…The chemistry of nitrogen-sulfur heteroatoms, containing the s-triazines nucleus, is presently a popular area of research. The s-triazine derivatives are found to posses biological activities including antitubercular (Dabhi et al, 1992), antitumor (Brzozowski et al, 2000), anticancer (Sanders et al, 1985) , sedative (Tobe et al, 1976), anti-inflammatory (Kambayashi et al, 1975;Saxena et al, 1994) and anthelmintic (Chauhan et al, 1994) . ammoniumdithiocarbamates are expected to possess pharmacological properties.…”