ChemInform Abstract: The Toxic and Sedative Bufadienolides of Kalanchoe daigremontiana Hamet et Perr.

Wagner, Harrieth; Lotter, H.; Fischer, M. H.

doi:10.1002/chin.198624332

Cited by 4 publications

(8 citation statements)

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“…The cardiotoxic activity of bersaldegenin-1,3,5-orthoacetate (3) was investigated in vitro using isolated rabbit and guinea pig hearts. A strong positive inotropic effect was shown [20,103]. Toxicity to cattle has been documented in earlier studies.…”

Section: Wound Healing Activitysupporting

confidence: 58%

“…1), mostly in conjunction with various bioactivities such as insecticidal and cytotoxic properties [11][12][13][14][15][16][17][18][19][20][21][22][23]. A characteristic structural feature is the 1,3,5-orthoacetate function, which is present in about half of these compounds.…”

Section: Bufadienolidesmentioning

confidence: 99%

“…Several compounds, including a phenanthrene [46], α-rhamnoisorobin (23), and further kaempferol rhamnosides (17,(19)(20)(21)(22) [28], showed antimicrobial activity.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

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Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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Section: Wound Healing Activitysupporting

confidence: 58%

Section: Bufadienolidesmentioning

confidence: 99%

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Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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“…These compounds reportedly possess sedative and positive inotropic properties, as well as central nervous system (CNS) related activities [22]. For safety assessment and quality control of phytomedicines containing B. pinnatum, detailed information on the metabolite profile of is required.…”

Section: Introductionmentioning

confidence: 99%

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

et al. 2013

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Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves and to identify chromatographic markers for quality control and safety assessment of medicinal preparations. Preliminary HPLC-PDA-ESIMS analyses revealed that flavonoid glycosides were the main UV-absorbing constituents in the MeOH extract of B. pinnatum. Two phenolic glucosides, syringic acid -D-glucopyranosyl ester (1) and 4'-O--D-glucopyranosyl-cis-p-coumaric acid (2), as well as nine flavonoids (3-11) including kaempferol, quercetin, myricetin, acacetin, and diosmetin glycosides were unambiguously identified by 1H and 2D NMR analysis after isolation from a MeOH extract. The flavonol glycosides quercetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside 7-O--D-glucopyranoside (3) and myricetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside (4) were new natural products. With the aid of HPLC-PDA-APCIMS and authentic references isolated from the related species B. daigremontianum, the presence of four bufadienolides, bersaldegenin-1-acetate (12), bryophyllin A (13), bersaldegenin-3-acetate (14), and bersaldegenin-1,3,5-orthoacetate (15) AbstractBryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders, and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves, and to identify chromatographic markers for quality control and safety

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“…Previous phytochemical studies on B. pinnatum led to the identification of bufadienolides and flavonoids, such as bersaldegenin-1-acetate, bryophyllin A, bersaldegenin-3-acetate, and bersaldegenin-1,3,5-orthoacetate, as well as glycosides of quercetin, myricetin, diosmetin, kaempferol, and acacetin [10]. A quantitative assay for determination of bufadienolides in B. pinnatum leaves and BPJ was developed and validated [11], considering their relevance with respect to safety issues and their pharmacological activities such as sedative, positive inotropic, and CNS active [12,13]. On the other hand, flavonoids reportedly also possess a broad spectrum of pharmacological activities [14], and thus may contribute to the pharmacological profile of B. pinnatum.…”

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confidence: 99%

Potential of Bryophyllum pinnatum as a Detrusor Relaxant: An in Vitro Exploratory Study

et al. 2017

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An earlier prospective, randomised, placebo-controlled clinical trial had suggested that might have potential in the treatment of overactive bladder. Here we investigated the effects of leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with .

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ChemInform Abstract: The Toxic and Sedative Bufadienolides of Kalanchoe daigremontiana Hamet et Perr.

Cited by 4 publications

References 1 publication

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

Potential of Bryophyllum pinnatum as a Detrusor Relaxant: An in Vitro Exploratory Study

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