ChemInform Abstract: Synthetic Routes to Coelenterazine and Other Imidazo[1,2‐a]pyrazin‐3‐one Luciferins: Essential Tools for Bioluminescence‐Based Investigations

Coutant, Eloi P.; Janin, Yves L.

doi:10.1002/chin.201608249

Cited by 1 publication

(1 citation statement)

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“…[43,46] This is a widespread phenomenon that can be observed in, among others, bacteria, dinoflagellates, worms, and insects. Several CL and BL systems have already been studied, [43,[45][46][47][48][49] enabling the development of new techniques that rely on a variety of intrinsic advantages: sensitivity, specificity, fast reaction rates, possibility of colour modulation, and high quantum yields. As such, BL and CL systems have gained several applications in the fields of sensing, pharmacy, biomedicine, and bioanalytics.…”

Section: Systemsmentioning

confidence: 99%

Photosensitizers and Their Applications

2022

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Photodynamic therapy (PDT) is a minimally-invasive anti-tumor therapeutic modality, known for its selectivity and limited side-effects. PDT has three fundamental requirements: a nontoxic photosensitizer (PS), light of a specific wavelength, and molecular oxygen. The anti-tumor therapeutic effect is triggered by the photo-activation of the PS via irradiation of the target tumor site with light of a specific wavelength. This leads to a photochemical reaction in which the PS generates cytotoxic reactive oxygen species (ROS), which lead to tumorselective cell destruction. Despite significant advantages, the necessity of an external light source impairs the use of PDT for most tumors, due to the poor penetration of light into deeply localized tissues. Given this, researchers have focused on developing strategies to improve the efficiency of this therapy and expand it for deeper tumors and metastatic cancer. One strategy is to use either chemi-(CL) or bioluminescent (BL) reactions as intracellular excitation sources of PSs for PDT. Namely, CL/BL are processes in which light is generated due to a chemical/biochemical reaction, without any light source, and therefore, can be used to excite the PS intracellularly. More importantly, an extra step can be taken and instead of using CL reactions as excitation sources, they can be used as the basis for tumor-selective and self-activating single-molecule drugs that are both the excitation source and the PS itself. In this chapter, we will provide a critical

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Section: Systemsmentioning

confidence: 99%

Photosensitizers and Their Applications

2022

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ChemInform Abstract: Synthetic Routes to Coelenterazine and Other Imidazo[1,2‐a]pyrazin‐3‐one Luciferins: Essential Tools for Bioluminescence‐Based Investigations

Abstract: Review: [117 refs.

Cited by 1 publication

References 79 publications

Photosensitizers and Their Applications

Photosensitizers and Their Applications

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