ChemInform Abstract: Synthesis of Pyrrolo[3,4‐e][1,4]diazepine Derivatives. Part l. 2,3‐Dihydro‐5‐aryl‐7‐aryl‐pyrrolo[3,4‐e][1,4]diazepine‐6‐thioxo‐8‐(lH,7H)‐ones.

Pyrrolidinetrione Derivatives: Synthesis And Applications in Heterocyclic Chemistry

“…A modification of the above route,53 leading to 1,4-diazepine derivatives 52, consisted in the formation of pyrrolidine derivatives by cyclocondensation between Schiff bases 59 of ethylenediamine (61) or aryl-3-oxo thioanilides and oxalyl chloride. The so obtained compounds 60 Scheme 18underwent intramolecular cyclization in alkaline medium to afford fused pyrrolo[3,4-e]-1,4-diazepines 52 (Scheme 19).54,55,59 All compounds of this series are of interest because of their potential biological activity. One of the sulfur analogs, 6-thioxopyrrolo[3,4-e]-1,4-diazepine, exhibits particularly strong analgesic and anti-inflammatory activity 57.…”