ChemInform Abstract: Synthesis of Metal Complexes of Antimalarial Drugs and in vitro Evaluation of Their Activity Against Plasmodium falciparum.

Abstract

272ChemInform Abstract The two well known antimalarials amodiaquine and primaquine react with corresponding metal salts in stoichiometric ratio to afford the 1:1 amodiaquine metal complexes (I) and the 2:1 or 3:1 primaquine complexes (II). These complexes are investigated by an in vitro microtechnique for their schizonticidal activity. The antimalarial activity of these metal complexes is of the same order as that of the corresponding drugs.