ChemInform Abstract: Synthesis and Study of Some Compounds Containing Oxazolone Ring, Showing Biological Activity.

Tandel, R. C.; Mammen, Denni

doi:10.1002/chin.200839111

Cited by 6 publications

(7 citation statements)

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“…Among all the synthesized compounds, oxazolone with 4-chlorobenzaldehyde shows more anti-inflammatory activity when compared with the other oxazolone derivatives [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Synthesis, Characterization, and Biological Evaluation of Oxazolone Analogs

Muthuboopathi

2018

Asian J Pharm Clin Res

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Objective: The main objective of the study is to synthesize some novel oxazolone derivatives to evaluate for anti-inflammatory activity.Methods: Acetylglycine was prepared using glycine and acetic anhydride, and the prepared acetylglycine was condensed with different aromatic aldehydes to get novel oxazolone derivatives. The synthesized compound was carried out the characterization by Fourier-transform infrared spectroscopy and find the anti-inflammatory by human red blood cell (HRBC) membrane stabilization method.Results: The anti-inflammatory activity was performed using novel oxazolone derivatives (Cpd1, Cpd2, Cpd3, and Cpd4) and nimesulide (as standard) on HRBC membrane stabilization method. The percentage protection was observed using colorimeter. The synthesized oxazolone was compared with the standard drug nimesulide for anti-inflammatory using HRBC membrane stabilizing method. All the synthesized oxazolone derivatives have shown the anti-inflammatory activity as that of standard. The results can be easily interpreted using histograms.Conclusions: Among all the synthesized compounds, oxazolone with 4-chlorobenzaldehyde shows more anti-inflammatory activity when compared with the other oxazolone derivatives.

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“…Among all the synthesized compounds, oxazolone with 4-chlorobenzaldehyde shows more anti-inflammatory activity when compared with the other oxazolone derivatives [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Synthesis, Characterization, and Biological Evaluation of Oxazolone Analogs

Muthuboopathi

2018

Asian J Pharm Clin Res

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“…Oxazolones having various pharmacological activities such as anticancer, ant diabetic, antifungal, antibacterial, Analgesic, Anti-inflammatory etc. But here we are mainly focusing on the Antibacterial activity of the synthesized compound [20][21][22][23] .…”

Section: Biological Activitymentioning

confidence: 99%

Synthesis of different α, β- unsaturated oxazolone derivatives

Phalke¹

2019

J. Drug Delivery Ther.

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Acetyl glycine were prepared from glycine acetic anhydride and then 2, 4-disubstituted Oxazol-5-one were prepared from acetyl glycine, substituted aldehydes, acetic anhydride, and sodium acetate as a catalyst. The formed product is evaluated and characterized by thin layer chromatography, infrared spectroscopy and melting point. The, β-unsaturated shows ability to react with various nucleophilic reagents for synthesis of new fused oxazole compounds.

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“…Oxazolin-5-ones are multifunctional due to the presence of C=C, C=N, and C=O bonds. Hence, they are important in the synthesis of natural products and pharmaceutical chemicals [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Substituted oxazoles are important as they are compatible in the preparation of biologically active molecules such as: anti-bacterial, antifungal, anti-inflammatory [2][3][4], analgesic [5], anticancer [6,7], anti-diabetic [8] and antiobesity [9] agents. Further, 2-phenyl-4-aryl methylidene-5-oxazolinones are useful for the synthesis of thiadiazoles and triazoles [10] which also exhibit antimycobacterial [11,12], antimycotic [13] and antidepressive [14] activities.…”

Section: Introductionmentioning

confidence: 99%

Zn(OCOCH3)2·2H2O Catalysed Efficient Preparation of 2-Phenyl-4-Arylmethylidene-5-Oxazolinones under Ultrasonic Condition

Azzam¹,

Khanum²,

Päsha³

2023

Catal Res

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2-Phenyl-4-arylmethylidene-5-oxazolinones were synthesized in very high yield by subjecting a mixture of an aryl aldehyde/heterocyclic aldehyde/cinnamaldehyde and hippuric acid in anhydrous acetic anhydride and catalytic Zn(OCOCH3)2·2H2O to ultrasonication at 35 KHz for 4 to 8 min. This method has many advantages: use of a green catalyst; yields are high, involves easy workup procedure, is energy efficient and economically feasible.

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ChemInform Abstract: Synthesis and Study of Some Compounds Containing Oxazolone Ring, Showing Biological Activity.

Cited by 6 publications

References 0 publications

Synthesis, Characterization, and Biological Evaluation of Oxazolone Analogs

Synthesis, Characterization, and Biological Evaluation of Oxazolone Analogs

Synthesis of different α, β- unsaturated oxazolone derivatives

Zn(OCOCH<sub>3</sub>)<sub>2</sub>·2H<sub>2</sub>O Catalysed Efficient Preparation of 2-Phenyl-4-Arylmethylidene-5-Oxazolinones under Ultrasonic Condition

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