ChemInform Abstract: Synthesis and Reaction of Acenaphthenequinones. Part 1

Abstract

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Synthesis and anticancer evaluation of novel acenaphtho [1,2-e]-1,2,4- triazine derivatives

“…acenaphthaquinone with nucleophiles, organic and inorganic reagents have been reviewed elsewhere [19]. In the continuation of our program to develop the chemistry of potentially bioactive heterocyclic compounds and in connection with our ongoing interests in this field [20][21][22], we represent a facile procedure for the synthesis of 9-(phenyl imino hydrazin)-acenaphtho[1,2-e]-1,2,4-triazine derivatives (8a-h) via four step condensation of thiosemicarbazide and acenaphtylene -9,10 Quinone to form acenaphtho [1,2-e]-1,2,4-triazine-9(8H)-thiones and subsequent reaction with benzyl chloride derivatives.…”

Novel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2)

“…Various reactions of acenaphthaquinone with nucleophiles, organic and inorganic reagents have been reviewed elsewhere [ 20 , 21 ]. In the framework of our program to develop the chemistry of potentially bioactive heterocyclic compounds [ 22 ] and in connection with our ongoing interests in this field [ 23 - 25 ], we represent here a facile procedure for the synthesis of 9-(alkylthio)-acenaphtho[1,2-e]-1,2,4-triazines via two step condensation of thiosemicarbazide and acenaphtylene-9,10-quinone to form acenaphtho[1,2-e]-1,2,4-triazine-9(8H)-thiones and subsequent reaction with benzyl chloride derivatives.…”