ChemInform Abstract: Synthesis and Biological Activity of the Nucleoside Analogues Based on Polyfluoroalkyl‐Substituted 1,2,3‐Triazoles.

Kanishchev, Oleksandr S.; Gudz, Ganna P.; Shermolovich, Yu. G.; Nesterova, N. V.; Zagorodnya, Svіtlana; Golovan, Anna

doi:10.1002/chin.201220200

Cited by 2 publications

(3 citation statements)

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“…91 Nucleosides and nucleoside analogs have long been an important class of medicinal agents, possessing anticancer and antiviral activity. 92,93 The synthesis protocol involves a sequence of glycosylation, photo-sensitized deoxygenation and deprotection reactions. In the first step, '- Scheme 26.…”

Section: Photochemical Stepmentioning

confidence: 99%

Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry

Politano

Oksdath‐Mansilla

2018

Org. Process Res. Dev.

146

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The research area of synthetic organic photochemistry is a powerful tool for creating both natural products and molecules with high structural complexity, in a simple way and under mild conditions. However, because of the challenges in scaling-up, it has been difficult to apply a photochemical reaction in an industrial process. Flow chemistry provides an opportunity for better control over the conditions of the reaction and, additionally, improved reaction selectivity and enhanced reproducibility. Taking into account that significant interest has focused on the use of flow photochemistry as a method for the synthesis of heterocycles and its applications in target-oriented synthesis over the last few years, the aim of this review is to highlight the recent efforts to apply flow photochemistry methodology to diverse reactions as a greener and more scalable process for the pharmaceutical and fine chemical industries. Additionally, the review highlights future perspectives in the development of scale-up strategies, combining photochemical reactions in the continuous flow multistep synthesis of organic molecules, being of interest for scientists and engineers alike.

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Section: Photochemical Stepmentioning

confidence: 99%

Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry

Politano

Oksdath‐Mansilla

2018

Org. Process Res. Dev.

146

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“…Ранее мы сообщали о синтезе новых фторсо-держащих аналогов нуклеозидов, проявляющих антивирусную активность [10], и фторсодержа-щих производных метиленбисфосфоновых кис-лот [11]. Целью настоящего исследования стала разработка методов синтеза фторсодержащих ми-метиков нуклеозид-дифосфатов из этих соедине-ний для последующего изучения их антивирус-ной активности.…”

Section: -{1-[4-перфторалкіл-5-(толіл-4-сульфоніл)-[123]триазол-2-unclassified

“…Аналоги нуклеозидов 6а, 6b, 9 по-лучены по методам, описанным ранее [10,12,13]. Для соединения 9 гидроксильные группы в поло-жении 2,3 фуранозного цикла были защищены вве-дением изопропенильного заместителя по извест-ной методике [14].…”

Section: экспериментальная частьunclassified

The synthesis of bisphosphonate analogues of nucleotides – derivatives of (α-phenyl)(α-fluoro)methylenebisphosphonic acids

Zasukha¹,

Guzyr²,

Gudz³

et al. 2014

J. org. pharm. chem.

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ChemInform Abstract: Synthesis and Biological Activity of the Nucleoside Analogues Based on Polyfluoroalkyl‐Substituted 1,2,3‐Triazoles.

Abstract: The addition of 2‐N‐chlorotriazoles (I) to dihydropyran followed by base‐promoted dehydrochlorination leads to nucleoside mimetics (IV).

Cited by 2 publications

References 1 publication

Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry

Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry

The synthesis of bisphosphonate analogues of nucleotides – derivatives of (α-phenyl)(α-fluoro)methylenebisphosphonic acids

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