ChemInform Abstract: Synthesis and Biological Activities of Selected Quinolone‐Metal Complexes

Singh, Ram; Debnath, Anamika; Rathore, Deepshikha

doi:10.1002/chin.201512297

Cited by 11 publications

(13 citation statements)

References 48 publications

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“…The organisms used in the present investigations included Staphylococcus aureus (S. aureus), Streptococcus features (S. features) and Bacillus subtillis (B. subtilis) (as gram-positive bacteria) and Proteus mirabilis (P. mirabilis), Pseudomonas aereuguinosa (P. aereuguinosa), and Escherichia coli (E. coli) (as gram-negative bacteria). The zone of inhibition of moxifloxacin and its metal complexes against gram-negative and gram-positive bacteria were then evaluated by the well diffusion method (De Almeida et al 2007;Efthimiadou et al 2008;Patel et al 2011;Singh et al 2013;Tavares et al 2004). The results of the bacterial screening of the synthesized compounds were recorded as shown in Table 6.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Seku¹,

Yamala

Kancherla³

et al. 2018

J Anal Sci Technol

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Methods: Moxifloxacin-Au(III) and Ag(I) metal complexes were prepared by adding corresponding aqueous solutions of Au(III) and Ag(I) metal salts to methanolic solution of Moxifloxacin. These metal complexes were characterized by physio-chemical techniques like UV-Vis, 1 H-NMR, FTIR, XRD, DSC, TGA, SEM and microanalytical data. The disc diffusion method was used to study the antibacterial activity of the Moxifloxacin-metal complexes.

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Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Seku¹,

Yamala

Kancherla³

et al. 2018

J Anal Sci Technol

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“…Nalidixic acid is the first member of quinolones [3]. Due to the narrow spectrum of nalidixic acid several modifications were made on the basis of structure activity relationship (SARS) to enhance the bactericidal spectrum and improve the pharmacokinetics properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Antifungal Studies of Cr(III) Complex of Norfloxacin and Bipiridyl Ligand

Debnath

Hussain

Masram

2014

Bioinorganic Chemistry and Applications

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A novel slightly distorted octahedral complex of Cr(III) of norfloxacin (Nor) with the formula [CrIII(Nor)(Bipy)Cl2]Cl·2CH3OH has been synthesized hydrothermally in the presence of a N-containing heterocyclic compound 2,2′-bipyridyl (Bipy). The complex was characterized with FT-IR, elemental analysis, UV-visible spectroscopy, and X-ray crystallography. Spectral studies suggest that the Nor acts as a deprotonated bidentate ligand. Thermal studies were also carried out. The synthesised complex was screened against four fungi Pythium aphanidermatum (PA), Sclerotinia rolfsii (SR), Rhizoctonia solani (RS), and Rhizoctonia bataticola (RB).

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“…By association with patterns obtained so far using OFL, in this study, it is possible to obtain a compound with a stoichiometric metal: ligand of 1:2 or 1:1 while ratio of 1:3 is unlikely [13][14][15][16][17][18][19][20][21]27]. In the mass spectrum (m/z 830.9) is highlighted the molecular ion Ag(OFL) 2 + , corresponding to ratio metal:ligand of 1:2 combination, and m/z 362.1 corresponding to the molecular ion of the free OFL. Metal complex is formed in this ratio, but not the entire amount of OFL has been included in the complex and obviously the Ag + ions from AgNO 3 have not been fully complexed.…”

Section: Ms Spectra Analysismentioning

confidence: 72%

“…Metal complexes have been synthesized with antimicrobial activity equal to or greater with the corresponding quinolone antibacterial. Research on the fluoroquinolone metal complexes has revealed also other biological effects: antifungal, antiparasitic, anticancer, anti-inflammatory, antioxidant and even insulin mimetic [2][3][4]. In the category of metal complexes with promising therapeutic effects are included those containing silver [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

A New Silver Complex with Ofloxacin – Preliminary Study

Rusu

Popescu

Imre

et al. 2016

Acta Medica Marisiensis

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Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin. Methods: To achieve our goals several spectroscopic methods (ultraviolet spectrophotometry, mass spectrometry, and Fourier transform infrared spectroscopy) and thermal methods (differential scanning calorimetry and thermogravimetric analysis) were used in order to elucidate the chemical structure of the complex. Results: Using mass spectrometry we established the stoichiometric ratio silver:ofloxacin as 1:2. Experimental data suggest a particular coordination for ofloxacin, as a monodentate ligand, in the formation of a complex with silver, through the nitrogen atom from the methyl-piperazine cycle. IntroductionDue to the excellent chelating properties of quinolone antibacterial several metal complexes of these substances were synthesized and studied for their possible antibacterial and antifungal activities. The silver ion is known for its antibacterial and antifungal properties. Fluoroquinolones are synthetic antibacterial agents, with broad spectrum activity, good oral absorption and bioavailability. The 4-oxo and 3-carboxyl groups of fluoroquinolones offer excellent chelating properties for metal ions. Silver complexes of fluoroquinolone antibacterial have the advantage of combining the antibacterial activity of the silver ion with the one of the fluoroquinolone. There are a large number of studies on the complexation of antibacterial fluoroquinolones with metal ions using different metals [1]. Metal complexes have been synthesized with antimicrobial activity equal to or greater with the corresponding quinolone antibacterial. Research on the fluoroquinolone metal complexes has revealed also other biological effects: antifungal, antiparasitic, anticancer, anti-inflammatory, antioxidant and even insulin mimetic [2][3][4]. In the category of metal complexes with promising therapeutic effects are included those containing silver [5][6][7][8][9][10].Complexation of antibacterial quinolones with silver combines the antibacterial activity of Ag (I) with the one of the quinolone. This complexation presents a particular coordination with the quinolone as the monodentate ligand

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ChemInform Abstract: Synthesis and Biological Activities of Selected Quinolone‐Metal Complexes

Cited by 11 publications

References 48 publications

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Synthesis, Characterization, and Antifungal Studies of Cr(III) Complex of Norfloxacin and Bipiridyl Ligand

A New Silver Complex with Ofloxacin – Preliminary Study

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