Synthesis, Characterization, and Antifungal Studies of Cr(III) Complex of Norfloxacin and Bipiridyl Ligand

Abstract

A novel slightly distorted octahedral complex of Cr(III) of norfloxacin (Nor) with the formula [CrIII(Nor)(Bipy)Cl2]Cl·2CH3OH has been synthesized hydrothermally in the presence of a N-containing heterocyclic compound 2,2′-bipyridyl (Bipy). The complex was characterized with FT-IR, elemental analysis, UV-visible spectroscopy, and X-ray crystallography. Spectral studies suggest that the Nor acts as a deprotonated bidentate ligand. Thermal studies were also carried out. The synthesised complex was screened against four fungi Pythium aphanidermatum (PA), Sclerotinia rolfsii (SR), Rhizoctonia solani (RS), and Rhizoctonia bataticola (RB).

Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect

“…Figure 1 shows the structure of the CIP-Bi-CHX composite, which was suggested from the above analysis. Similar structures have been proposed for antibiotic-based complexes [ 18 , 19 , 21 ], including quinolone complexes with the participation of bipyridine [ 18 , 19 ].…”

“…Based on the knowledge that the ligands in metal complexes can be the ions or neutral molecules containing the atoms with free electron pairs (in particular N, O, halogens) such as carboxylate [ 19 ], triethylenetetramine, bipyridine [ 18 , 19 ], biguanide [ 20 , 29 ], the new composites (hybrids) were synthetized by covalently combining fluoroquinolone antibiotics and the biguanide derivatives with metal ion.…”

“…Nuclear magnetic resonance (NMR) spectroscopy and Fourier transform infrared spectroscopy (FTIR) are the commonly used methods for the confirmation of synthesis and structural characterization of a novel chemical framework [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The spectroscopic studies were used: (i) For the characterization of metal-complexes [ 17 , 18 , 19 , 20 , 21 , 22 , 24 , 32 , 33 ] such as metalloantibiotics [ 21 , 22 ], including metallofluoroquinolones [ 18 , 19 , 22 , 26 , 33 ] and metal complexes with chlorhexidine [ 20 , 24 ], (ii) for the analysis of the decomposition of metal-complexes [ 20 ], (iii) for the characterization of inclusion compounds [ 25 ], composites/mineral composites [ 27 , 28 , 31 , 32 ] and (iv) for the examination of interactions between the components [ 23 ]. Infrared (IR) spectroscopic method, especially the Attenuated Total Reflectance (ATR) technique and NMR spectroscopic measurements were often applied to confirm the coordination of the ligands to metal ions and to find out the possible coordination sites in the metallo-organic structures [ 17 ].…”

Synthesis, Characterisation & Antimicrobial Studies of Some Metal Complexes of Norfloxacin

“…The complex shows more activity as compared with the standard ligand indicating that metal complexation enhances the activity of the parent ligand; this may be explained by chelation theory 15,16 according to which chelation reduces the polarity of the ligand and the central metal atom because of the delocalization of electrons over the whole chelate ring increases, which favours permeation of the complexes through the lipid layer of the cell membrane…”

Preparation and spectroscopic studies of some nano copper and nickel Schiff base complexes and their applications as colouring pigments in protective paints industry.

“…The two bands observed at 1543, 1437 cm -1 and 1580,1436 cm -1 attributed to ʋ as and ʋ s carboxylic modes of Cu and Ni co mp lexes respectively, elucidate the presence of acetate ion in the proposed structures in Fig. 1 [9][10][11].…”