ChemInform Abstract: Synthesis and Biological Evaluation of 3‐(Phthalimidomethyl)‐4‐(5‐substituted isoxazoline and pyrazoline) Substituted Benzanilides.

Abstract

Isoxazole derivatives R 0240Synthesis and Biological Evaluation of 3-(Phthalimidomethyl)-4-(5-substituted isoxazoline and pyrazoline) Substituted Benzanilides. -A variety of phthalimidomethyl derivatives of isoxazoline (IX) (20 examples) and pyrazoline (X) is synthesized and evaluated for antibacterial and antifungal, anthelmintic and hypoglycemic activities. -(SAHU*, S. K.; AZAM, M. A.; BANERJEE, M.; CHOUDHURY, P.; SUTRADHAR, S.; PANDA, P. K.; MISRO, P. K.; J. Indian Chem. Soc. 84 (2007) 10, 1011-1015; Univ. Dep. Pharm. Sci., Utkal Univ., Bhubaneswar 751 004, India; Eng.) -H. Toeppel 33-137

Analgesic, anti-inflammatory, antipyretic and toxicological evaluation of some newer 3-methyl pyrazolone derivatives

“…Pyrazolone ring system represents an important class of compounds not only for their theoretical interest but also for their anti-inflammatory, analgesic, antipyretic (Badaweya et al, 1998), hypoglycemic agent (Das et al, 2008), fungicide (Singh and Singh, 1991), antimicrobial (Sahu et al, 2007) and some of them have been tested as potential cardiovascular drugs (Yukihito et al, 2006). In the recent year, research is focused on existing molecules and their modifications in order to reduce their side effects and to explore their other pharmacological and biological effects.…”

Synthesis, Characterization and Antimicrobial Screening of New Schiff Bases Linked to Phthalimidyl Phenyl Sulfonate Moiety

“…(SO 2 ) respectively. Finally FTIR spectra of the new Schiff bases (5)(6)(7)(8)(9)(10)(11) showed disappearance of absorption band at 1674 cm -1 belong to (C=O) ketone and appearance of clear strong absorption band at (1681-1690) cm -1 due to (C=N) imine.…”

“…In the third step the prepared imide (2) was introduced in chlorosulfonation reaction via treatment with chlorosulfonic acid producing compound (3) which in turn was introduced in the fourth step in esterification reaction with 4-hydroxy acetophenone producing compound (4). In the final step of this work the prepared new ketone (phthalimidyl phenyl sulfonate acetophenone) (4) was introduced in condensation reaction with different primary aromatic amines producing the desired target Schiff bases (5)(6)(7)(8)(9)(10)(11).…”

“…The mixture was refluxed for four hours then cooled to room temperature and the obtained precipitate was filtered, dried and purified by recrystallization from a suitable solvent. Physical properties of compounds (5)(6)(7)(8)(9)(10)(11) are listed in Table (2).…”

“…Similarly phthalimides which are bicyclic non-aromatic nitrogen heterocycles are important compounds with a variety of applications and a wide range of properties [6][7][8]. Generally they are used as starting materials and intermediates for the synthesis of many types of alkaloids and pharmacophores, synthesis of pesticides and lately are being under intense biomedical research due to their important biological effects [9][10][11][12].…”