ChemInform Abstract: Synthesis and Antimicrobial Activity of 5‐(2‐Aminothiazol‐4‐yl)‐3,4‐dihydro‐4‐phenylpyrimidin‐2(1H)‐one (IV).

Lanjewar, Kushal R.; Rahatgaonkar, Anjali M.; Chorghade, Mukund S.; Saraf, Binda D.

doi:10.1002/chin.201017163

Cited by 3 publications

(3 citation statements)

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“…In the view of this observation and extension of earlier work, we have synthesized 2-(4-methoxyphenyl)-8-(methylthio)-6-oxo-4phenyl-1,6,9,9a-tetrahydro-2H-pyrimido[1,2-a] pyrimidine-7-carbonitrile (3) by using6-(4-methoxyphenyl)-4-phenyl-1,6dihydropyrimidin-2-amine (2)[27][28] and ethyl 2-cyano-3, 3-bis(methylthio)acrylate. 6-(4-methoxyphenyl)-4-phenyl-1,6dihydropyrimidin-2-amine (2) is prepared by the reaction of 3-(4-methoxyphenyl)-1-phenyl prop-2-en-1-one (1)chalcone[29][30] with guanidine nitrate in the presence of alcoholic potassium hydroxide under reflux condition.II.METHODS Melting points were determined in open capillary tubes and are uncorrected.…”

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confidence: 74%

Synthesis of Novel Oxo Pyrimido Pyrimidine and Their Derivatives

Jadhav¹,

Jadhav²,

Kale³

et al. 2022

IJRASET

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Pyrimidine derivatives are synthesized to possess various pharmacological and biological activities. In the present work, we have synthesized 3-(4-methoxyphenyl)-1-phenyl prop-2-en-1-one (1) (chalcone) by using 4-methoxybenzaldehyde and acetophenone in the presence of alcoholic KOH by Claisen-Schmidt condensation reaction. After purification and characterization by physical and spectral methods, The synthesized chalcone have been converted into 6-(4-methoxyphenyl)-4- phenyl-1,6-dihydropyrimidin-2-amine (2) by treating with guanidine nitrate in the presence of alcoholic KOH. The structure (2) has been characterized by spectral analysis. The synthesized compound (2) is further reacted with ethyl 2-cyano-3, 3-bis (methylthio)acrylate in the presence of catalytic amount of potassium carbonate in DMF under reflux condition to givenovel 2- (4-methoxyphenyl)-8-(methylthio)-6-oxo-4-phenyl-1,6,9,9a-tetrahydro-2H-pyrimido[1,2-a] pyrimidine-7-carbonitrile(3) in good yields. The compound (3) possesses replaceable methylthio (-SCH3) group at 8 position. The compound (3) is further reacted with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 2-(4-methoxyphenyl)-8-substituted-6-oxo-4-phenyl-1,6,9,9a-tetrahydro-2H-pyrimido[1,2-a]pyrimidine-7-carbonitrile in good yields.

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mentioning

confidence: 74%

Synthesis of Novel Oxo Pyrimido Pyrimidine and Their Derivatives

Jadhav¹,

Jadhav²,

Kale³

et al. 2022

IJRASET

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“…Fused pyrimidines, 29 chromenopyrimidine, 30 and pyrimidines have also been reported as antiviral, antitumor, anti-inflammatory, antihypertensive activities, 31−33 calcium channel modulators, 34 and antimicrobial agents. 35−37 Coumarins and their derivatives (Figure 1A) such as warfarin, coumatetralyl, and difenacoum are used as an anticoagulant, whereas phenprocoumon and bromadiolone have antiviral and potent rodenticide, respectively. 38 Carbochromen 39 is an effective coronary vasodilator.…”

Section: Introductionmentioning

confidence: 99%

“…Thiazole moiety is a ubiquitous scaffold and has involved in many natural and synthetic molecules having interesting activities such as antiviral, anticancer, antimicrobial, anticonvulsant, antiparkinson, and anti-inflammatory activities. − Similarly, coumarin moieties have involved in plants and have shown anticoagulation, antiviral, anti-inflammatory, antibacterial, and anticancer activities. Fused pyrimidines, chromenopyrimidine, and pyrimidines have also been reported as antiviral, antitumor, anti-inflammatory, antihypertensive activities, − calcium channel modulators, and antimicrobial agents. − Coumarins and their derivatives (Figure A) such as warfarin, coumatetralyl, and difenacoum are used as an anticoagulant, whereas phenprocoumon and bromadiolone have antiviral and potent rodenticide, respectively . Carbochromen is an effective coronary vasodilator.…”

Section: Introductionmentioning

confidence: 99%

Metal-Free Construction of Fused Pyrimidines via Consecutive C–C and C–N Bond Formation in Water

et al. 2018

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A facile and efficient protocol has been developed for mild construction of fused pyrimidines via l -proline-catalyzed reaction of 4-hydroxy coumarins, aldehydes, and 2-aminobenzothiazoles/urea. The reaction has been carried out rapidly and efficiently in water under mild and metal-free conditions. Current etiquette has efficiently synthesized the heterocycles and avoids the use of hazardous solvents over conventional organic solvents. A plausible reaction mechanism has been established in this study. This study represents the first case in which l -proline as a homogeneous catalyst has been explored in the synthesis of fused pyrimidines in water in view of simple procedure and acceptable efficiency. This method gives the target product in excellent yield with ease of workup.

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Synthesis, Characterization and Anti-Microbial Activity of Novel Pyramidine Derivatives

Kumar¹,

Sumanjali²,

Chandana³

et al. 2021

J. Drug Delivery Ther.

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Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring. Three nucleobases found in nucleic acids, cytosine (C), thymine (T), and uracil (U), are pyrimidine derivatives. A pyrimidine has many properties in common with pyridine, as the number of nitrogen atoms in the ring increases the ring pi electrons become less energetic and electrophilic aromatic substitution gets more difficult while nucleophilic aromatic substitution gets easier. Chalcones react with aminoguanidine to give intermediate compounds which on further reacts with substituted ketones to give Pyramidine derivatives. A total of 6 compounds were synthesized from one scheme and they were recrystallized by appropriate solvents. They were identified and characterized by various spectral methods. In the present study, all synthesized compounds tested for anti bacterial activity and anti-fungal activity. They shown significant activity when compared with standard drug Streptomycin and Miconazole respectively. Keywords: Pyramidines, Characterization, Streptomycin, Miconazole, Anti-microbial activity.

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ChemInform Abstract: Synthesis and Antimicrobial Activity of 5‐(2‐Aminothiazol‐4‐yl)‐3,4‐dihydro‐4‐phenylpyrimidin‐2(1H)‐one (IV).

Cited by 3 publications

References 0 publications

Synthesis of Novel Oxo Pyrimido Pyrimidine and Their Derivatives

Synthesis of Novel Oxo Pyrimido Pyrimidine and Their Derivatives

Metal-Free Construction of Fused Pyrimidines via Consecutive C–C and C–N Bond Formation in Water

Synthesis, Characterization and Anti-Microbial Activity of Novel Pyramidine Derivatives

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