ChemInform Abstract: Synthesis and Antimicrobial Activities of a New Series of 4‐S‐[41‐Amino‐51‐oxo‐61‐substituted Benzyl‐41, 51‐Dihydro‐11,21,4 1‐triazin‐3‐yl]mercaptoacetyl‐3‐arylsydnones.

Hegde, Jyothi C.; Girisha, K. S.; Adhikari, Adithya; Kalluraya, Balakrishna

doi:10.1002/chin.200917171

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“…Corresponding author: Wasan M. Abd alanewasan@gmail.com 1,2,4-Triazine derivatives are good type in many biologically fields, such as antimicrobial (6) , antibacterial (7) , antifungal (8) and anticancer (9) . Furthermore, 1,2,4-triazole ring systems have a wide spectrum from biological activities, Antibacterial (10) and antifungal (11) .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Study the Biological Activity of New Heterocyclic Compounds Derived From Hydrazide Derivatives

2020

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The work involves synthesis of new compounds derived from 2-substituted-3-thio-acetohydrazide-1,2,4-triazin. The subsituted hydrazine thiocarbothioamide [IV] was obtained via reaction of hydrazide compound [III] with ammonium thiocyanate and HCl. The cyclization of compound [IV] in 4% NaOH led to formation 1,2,4-triazoles [V], which were refluxed with chloro-ethylacetate in ethanol and sodium acetate to give compound [VI]. Condensation of ester-compound [VI] with hydrazine (80%) led to formation new hydrazide compounds [VII]. Ring closure reaction of compound [VII] with 4-aminbenzoic acid in POCl 3 give 1,3,4-oxadiazoles [VIII]. Compound [VIII] was reacted with sub. benzaldehyde to form compounds of Schiff bases [IX] a-d . The synthesized compounds were diagnosed via IR, Mass and 1 HNMR spectral data. Many of synthesized compounds were examined against activity of antibacterial: gram (+) (Bacillus subtitis, staphylococcus aureus) and gram (-): (E.coli bacteria) and candida tropicalis fungial. To ensure the safety of the synthesis compounds the toxicity was examined.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Study the Biological Activity of New Heterocyclic Compounds Derived From Hydrazide Derivatives

2020

IJFMT

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ChemInform Abstract: Synthesis and Antimicrobial Activities of a New Series of 4‐S‐[4¹‐Amino‐5¹‐oxo‐6¹‐substituted Benzyl‐4¹, 5¹‐Dihydro‐1¹,2¹,4 ¹‐triazin‐3‐yl]mercaptoacetyl‐3‐arylsydnones.

Abstract: triazin-3-yl]mercaptoacetyl-3-arylsydnones. -Most of the novel sydnone derivatives such as (III) show antimicrobial and antifungal activities. -(HEGDE, J. C.; GIRISHA, K. S.; ADHIKARI, A.; KALLURAYA*, B.; Eur.

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Synthesis and Study the Biological Activity of New Heterocyclic Compounds Derived From Hydrazide Derivatives

Synthesis and Study the Biological Activity of New Heterocyclic Compounds Derived From Hydrazide Derivatives

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