Synthesis and Study the Biological Activity of New Heterocyclic Compounds Derived From Hydrazide Derivatives
Abstract:The work involves synthesis of new compounds derived from 2-substituted-3-thio-acetohydrazide-1,2,4-triazin. The subsituted hydrazine thiocarbothioamide [IV] was obtained via reaction of hydrazide compound [III] with ammonium thiocyanate and HCl. The cyclization of compound [IV] in 4% NaOH led to formation 1,2,4-triazoles [V], which were refluxed with chloro-ethylacetate in ethanol and sodium acetate to give compound [VI]. Condensation of ester-compound [VI] with hydrazine (80%) led to formation new hydrazide… Show more
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