ChemInform Abstract: Synthesis and Anticonvulsive Activity of 1‐R‐3‐Acetonyl‐3‐hydroxy Oxindole Oximes and Their Derivatives.

Gevorkyan, K. A.; Papayan, G. L.; Chshmarityan, S. G.; Paronikyan, R. G.; Akopyan, N. E.; Engoyan, A. P.

doi:10.1002/chin.198736175

Cited by 1 publication

(1 citation statement)

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“…These compounds are also obtained in aldolic and related condensations with acetone 394 or its oxime 395 ; aromatic 396,397 and heteroaromatic methylketones 398,399 ; cyclic alkylketones 400 ; acetates 401 ; propionates 402 ; acetoacetates 403 ; cyanoacetates 404 ; nitroalkanes 405 ; benzodiazepinones 406 ; imidazolinones 407 ; indoles 408 ; 2-methylquinolines 409 ; pyrazinones 410 ; thiazolidinediones [411][412][413][414][415] and xanthinones 416 In the reaction of isatins with some cyclic ketones, such as 4-hydroxy-2H-benzopyran-2-one 417 , the initial dioxindole formed reacts with a second equivalent of the ketone yielding a 3,3-disubstituted oxindole.…”

Section: Scheme 96mentioning

confidence: 99%

The chemistry of isatins: a review from 1975 to 1999

Silva¹,

Garden²,

Pinto³

2001

J. Braz. Chem. Soc.

845

447

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Isatinas (1H-indol-2,3-diona) são compostos de grande versatilidade sintética, podendo ser utilizados na obtenção de diversos sistemas heterociclos, como derivados indólicos e quinolínicos, o que as tornam importantes matérias-primas na síntese de fármacos. Isatinas também têm sido detectadas em tecidos de mamíferos, o que tem despertado o interesse em seu estudo como moduladores em diversos processos bioquímicos. Os avanços na aplicação de isatinas em síntese orgânica, bem como na compreensão de seus efeitos biológicos e farmacológicos nos últimos vinte e cinco anos encontram-se relatados nesta revisão e seus respectivos materiais suplementares.Isatins (1H-indole-2,3-dione) are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds, such as indoles and quinolines, and as raw material for drug synthesis. Isatins have also been found in mammalian tissue and their function as a modulator of biochemical processes has been the subject of several discussions. The advances in the use of isatins for organic synthesis during the last twenty-five years, as well as a survey of its biological and pharmacological properties are reported in this review and in the accompanying supplementary information.

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