ChemInform Abstract: SWIETENONE, THE FIRST NATURAL T‐BUTYL KETONE, FROM CHLOROXYLON SWIETENIA

Abstract

Swietenon stellt das erste in der Natur vorkommende tert‐Butylketon (I) dar.

Isolation, Structure, and Functional Elucidation of a Modified Pentapeptide, Cysteine Protease Inhibitor (CPI-2081) from Streptomyces Species 2081 that Exhibit Inhibitory Effect on Cancer Cell Migration

“…[29][30][31][32] A very unusual compound containing tertiary butyl group, t-bu ketone coumarin swietenone, was isolated from Chloroxylon swietenia. 33 Here, we describe the isolation and structure elucidation of novel tertiary butyl containing cysteine protease inhibitor (compound 1), a mixture of two very similar but distinctly modified peptides in approximate molar proportion of 35:65. As evidenced both by biochemical analysis (Table 1) and NMR analysis (Table 2, Figure 1A, Figure 1B).…”

“…Compounds bearing a t -butyl group are very rare in nature and are mostly isolated from marine sponges and include peptides, terpenes, carbinols, esters, and ketone. − A very unusual compound containing tertiary butyl group, t -bu ketone coumarin swietenone, was isolated from Chloroxylon swietenia . Here, we describe the isolation and structure elucidation of novel tertiary butyl containing cysteine protease inhibitor (compound 1 ), a mixture of two very similar but distinctly modified peptides in approximate molar proportion of 35:65.…”