Isolation, Structure, and Functional Elucidation of a Modified Pentapeptide, Cysteine Protease Inhibitor (CPI-2081) from <i>Streptomyces Species</i> 2081 that Exhibit Inhibitory Effect on Cancer Cell Migration

Singh, Jay; Tamang, Sudarsan; Rajamohanan, P. R.; Jima, N. C.; Chakraborty, Goutam; Kundu, Gopal C.; Gaikwad, Sushma; Khan, M. Islam

doi:10.1021/jm9014179

Cited by 11 publications

(3 citation statements)

References 38 publications

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“…In fact, the biological information of a protein sequence appears to reside in short aa strings. (31) A minimotif of only five residues can determine or inhibit essential cellular functions and processes such as cell adhesion and nerve regeneration, (32,33) apoptosis, (34) cancer cell proliferation (35) or migration, (36) thrombin activity, (37) and angiogenesis. (38) Moreover, it is well known that a pentapeptide represents a minimal recognition unit at the basis of the immune response, (39,40) and has an immunotherapeutic potential.…”

Section: Resultsmentioning

confidence: 99%

A peptide talk between JC virus and the human host: from silent infection to autoimmunity

Lucchese¹

2012

Immunopharmacology and Immunotoxicology

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Analysis of JC virus (JCV) polyprotein for peptide sharing with the human proteome reveals that the virus has hundreds of pentapeptide sequences in common with the human proteins. The datum is interesting in light of the fundamental role exerted by short amino acid sequences in protein-protein interactions and, consequently, in biochemical reactions and immune recognition. Searching for new approaches to understand the JCV infection scenarios, from the immunoevasion phenomenon underlying the viral asymptomatic stay in the human host to the (re)activation phase and associated pathogenic sequelae, the present study describes the diffuse pentapeptide communication network between JCV and the human host.

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Section: Resultsmentioning

confidence: 99%

A peptide talk between JC virus and the human host: from silent infection to autoimmunity

Lucchese¹

2012

Immunopharmacology and Immunotoxicology

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“…39), isolated from a biologically active culture supernatant of Streptomyces sp. NCIM2081 by Sihgh et al in 2010, as the cysteine protease inhibitor, it is found that nanomolar concentration of compounds CPI-2081a is able to inhibit papain hydrolytic activity, it also showed significantly inhibitory activity of tumor cell migration at sub cytotoxic concentration [118,119].…”

Section: Indole-based Natural Products and Their Antiviral Activitymentioning

confidence: 99%

A review on recent developments of indole-containing antiviral agents

Zhang

Chen

Yang

2015

European Journal of Medicinal Chemistry

704

215

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Indole represents one of the most important privileged scaffolds in drug discovery. Indole derivatives have the unique property of mimicking the structure of peptides and to bind reversibly to enzymes, which provide tremendous opportunities to discover novel drugs with different modes of action. There are seven indole-containing commercial drugs in the Top-200 Best Selling Drugs by US Retail Sales in 2012. There are also an amazing number of approved indole-containing drugs in the market as well as compounds currently going through different clinical phases or registration statuses. This review focused on the recent development of indole derivatives as antiviral agents with the following objectives: 1) To present one of the most comprehensive listings of indole antiviral agents, drugs on market or compounds in clinical trials; 2) To focus on recent developments of indole compounds (including natural products) and their antiviral activities, summarize the structure property, hoping to inspire new and even more creative approaches; 3) To offer perspectives on how indole scaffolds as a privileged structure might be exploited in the future.

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“…A mixture of two peptide metabolites from Streptomyces NCIM 2081 (Fig. 4) exhibited potent inhibitory action against papain and significantly inhibited tumor cell migration at subcytotoxic concentrations, indicating its remarkable potential to be developed as antimetastatic drug (Singh et al, 2010). …”

Section: Inhibitors From Natural Sourcesmentioning

confidence: 99%