ChemInform Abstract: Supercritical Fluid Technology in Pharmaceuticals

Jain, Tripti A.; Jain, Vipin; Pandey, Rajat Kumar; Daharwal, SJ; Shukla, Shefali; Vyas, Anoop Lal

doi:10.1002/chin.201031279

Cited by 3 publications

(3 citation statements)

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“…However, these methods are obviously laborious, time‐consuming and large amounts of organic solvent needed. As an innovative solvent‐extraction technology used energy of microwave irradiation to heat solvents quickly and efficiently, microwave‐assisted extraction (MAE) offers a superior alternative to several thermal applications and has many advantages over conventional solid‒liquid extraction methods, it was widely used to extract target compounds from various raw materials in the last decades []. Waksmundzka‐Hajnos et al [] studied the extraction yields of furanocoumarins in Archangelica officinalis Hoffm.…”

Section: Introductionmentioning

confidence: 99%

Separation and purification of furanocoumarins from Toddalia asiatica (L.) Lam. using microwave‐assisted extraction coupled with high‐speed counter‐current chromatography

He-yuan

Xiao

2012

J of Separation Science

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A method of microwave-assisted extraction coupled with high-speed counter-current chromatography was established for separation and purification of isopimpinellin, pimpinellin and phellopterin from Toddalia asiatica (L.) Lam. The conditions of MAE including the extraction solvent, size of sample, solid/liquid ratio, extraction temperature and extraction time were optimized by a mono-factor test. That is, 2.0 g dried powder of T. asiatica (L.) Lam of 0.30-0.15 mm size was extracted with 20 mL (solid/liquid ratio of 1:10, g/mL) methanol under 50 °C for 1 min. The crude extract was separated and purified by high-speed counter-current chromatography with hexane-ethyl acetate-methanol-water (5:5:5.5:4.5, v/v/v/v) solvent system. 0.85 mg/g of isopimpinellin, 2.55 mg/g of pimpinellin and 0.95 mg/g of phellopterin were obtained from original sample in one-step within 240 min, the purity determined by high performance liquid chromatography was 95.0%, 99.1% and 96.4%, respectively. Their chemical structures were further identified by mass spectroscopy and nuclear magnetic resonance spectroscopy. The results demonstrated that microwave-assisted extraction coupled with high-speed counter-current chromatography was a feasible, economical and efficient technique for rapid extraction, separation and purification of effective compounds from natural products.

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Section: Introductionmentioning

confidence: 99%

Separation and purification of furanocoumarins from Toddalia asiatica (L.) Lam. using microwave‐assisted extraction coupled with high‐speed counter‐current chromatography

He-yuan

Xiao

2012

J of Separation Science

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“…The choice of extraction solvents depends on factors such as solvent penetration into the matrix, solubility of the target compound, interaction between the solvent and plant matrix, and the solvent's capability to heat up due to microwave energy absorption. Solvents with high dielectric constant and dielectric loss constant theoretically have a high capacity to absorb microwave energy [39,44]. Accordingly, water, ethanol, acetone, methanol, propan-2-ol, and acetonitrile are considered suitable solvents for the MAE of plant bioactive compounds based on their dielectric properties [45,46].…”

Section: Catechinmentioning

confidence: 99%

Optimisation Catechin Extract on Black Tea Waste (BTW) using Microwave Assisted Extraction (MAE) (Time Extraction and Ethanol Concentration as Parameters)

Tartillah

2024

BIO Web Conf.

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Remaining catechins from Black Tea processing can be found in significant amounts in tea waste. When using a 60% methanol organic solvent in the Microwave Assisted Extraction (MAE) method, as opposed to other methods, the extraction of black tea waste (BTW) results in a high polyphenol concentration. With a focus on yield extraction, antioxidant content, and catechin levels, the goal of this study is to identify the ideal alcohol solvent concentration and the impact of microwave heating duration on the extraction of BTW. The research uses a 2-factor Central Composite Design (CCD), which was created using Design Expert 9 Free Trial software. Factor I represents the microwave heating duration (4–8 minutes), while factor II represents the concentration of the alcohol solvent (60–80%). According to the results, the ideal conditions—a 62.74% alcohol solvent concentration and an 8-minute heating period—got a desirability of 74.20%. The expected yield was 54.8399% under these ideal circumstances, the antioxidant content (IC50) was 7.50516 ppm, and the catechin level was 92.0558%. The yield, antioxidant content (IC50), and catechin level of the verification results were 54.62%, 14.38847, and 94.74%, respectively, with response variations of 0.403%, 47.43%, and 2.833%.

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“…As a result, the cell expands (swelling) and the pressure pushes the cell wall from within, stretching and breaking the cell. The destruction of plant cells facilitates the exit target compounds and extracted [4]. High temperatures of microwave radiation can hydrolyze the ether bonds on the cell wall components of plants, such as cellulose.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Sodium Alginate from Sargassum sp. using Microwave-Assisted Extraction (MAE)

Ruslan

Amir

wiraningtyas

2019

J. Pure App. Chem. Res.

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The method used in alginate extraction has been using conventional heating. Lately, Microwave-Assisted Extraction (MAE) has been widely used to extract active compounds from natural ingredients. This study aims to extract sodium alginate from Sargassum sp. using MAE method. This research was conducted by determining the optimum power level and extraction time using a commercial microwave. Power level optimization is carried out at level 70; 80; 90 and 100, while extraction time is carried out for 15; 16; 17 and 18 minutes. The results showed that sodium alginate products were obtained at levels 70, 80, 90 and 100, respectively 0.5%; 37.13%; 23.36% and 1.2%. While sodium alginate products are obtained at variations in extraction time for 15; 16; 17 and 18 minutes were obtained respectively 27.4%; 37.13%; 26.1% and 25.76%. The characterization of sodium alginate products was carried out by analysis of water content, ash content, brightness, and viscosity in the sequence obtained by 14.43%; 14.63%; 78.62 and 95.00 cps. The results of the analysis of heavy metal content obtained that the product of sodium alginate extracted did not contain metal Pb and Hg. FTIR spectra results showed the presence of hydroxyl (-OH) functional groups at wave numbers 3448.7 cm-1 and 1620.21 cm-1 ; C-H bond at 2931.8 cm-1 ; alkene group at 2337.7 cm-1 ; sodium (Na) bond at 1419.61 cm-1 ; carbonyl group at 1095.57 cm-1 and carboxylic and ketone groups at 1033.85 cm-1. Based on the results of the characterization proving that the product obtained is a sodium alginate compound.

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ChemInform Abstract: Supercritical Fluid Technology in Pharmaceuticals

Cited by 3 publications

References 0 publications

Separation and purification of furanocoumarins from Toddalia asiatica (L.) Lam. using microwave‐assisted extraction coupled with high‐speed counter‐current chromatography

Separation and purification of furanocoumarins from Toddalia asiatica (L.) Lam. using microwave‐assisted extraction coupled with high‐speed counter‐current chromatography

Optimisation Catechin Extract on Black Tea Waste (BTW) using Microwave Assisted Extraction (MAE) (Time Extraction and Ethanol Concentration as Parameters)

Extraction of Sodium Alginate from Sargassum sp. using Microwave-Assisted Extraction (MAE)

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