ChemInform Abstract: SULFONAMIDE DERIVATIVES OF 1‐(3‐INDOLYL)‐1,2‐DIHYDROISOQUINOLINE

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

“…Skrypnik and co-workers reported a three-component reaction using sulfonyl chlorides as the activating species. 6 Their procedure used two equivalents of isoquinoline, the second equivalent acting as a base. For library synthesis, this is undesirable as it wastes potentially valuable starting materials and complicates purification.…”