ChemInform Abstract: Studies on Synthesis of 2‐Acetylbenzimidazole and Related Benzimidazole Derivatives.

Ramaiah, K.; Grossert, J. Stuart; Hooper, D. L.; Dubey, P. K.; Ramanatham, J.

doi:10.1002/chin.200019111

Cited by 6 publications

(8 citation statements)

References 1 publication

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“…The electrical conductance values of complexes were determined in DMF on Systonic conductivity Meter Bridge at 30-31 ∘ C. The results of measurements are given in Tables 1 and 2. Ligand molecules (H 2 bmctz, H 2 L-1 or H 2 bpmctz, H 2 L-2) were prepared by condensing 2-acetylbenzimidazole or 2-benzoylbenzimidazole [33] with morpholine-Nthiohydrazide [34] in aqueous ethanol containing a little amount of acetic acid. 2-Acetylbenzimidazole or 2benzoylbenzimidazole in situ was prepared by oxidation of 1-(1H-benzimidazol-2-yl)ethanol and 1-(1H-benzimidazol-2-yl)phenylmethanol [35] with chromic acid [33]. The 0.1 mole of 2-acetylbenzimidazole in 100 mL aqueous ethanol containing 2 mL acetic acetic acid was refluxed with 0.12 mole of aqueous ethanolic solution of morpholine-N-thiohydrazide(morpholine-4-carbothiohydrazide) on a steam bath for two hours.…”

Section: Methodsmentioning

confidence: 99%

Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions

Bala

Mishra

2014

International Journal of Inorganic Chemistry

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The coordination complexes of bivalent metal ions with N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide (H2bmctz, H2L-1) and N-[(1E)-1-(1H-Benzimidazol-2-yl)(phenyl)methylidene] morpholine-4-carbothiohydrazide (H2bpmctz, H2L-2) were prepared and their neutral, monoanionic, and dianionic forms of ligands of compositions [M(H2L)X2] (M=CoII, NiII, CuII, ZnII, CdII, or PdII, X=Cl− or Br−, and H2L=H2L-1 or H2L-2), [M(HL)2]nH2O where (M=CoII, CuII, MnII, NiII, ZnII or CdII, H2L=H2L-1 or H2L-2, and n = 0 or 2), and [MLB]nB (M=CuII, NiII, ZnII, CdII, or PdII, B=H2O, Py, or Y-pic, n = 0 and n = 1 if B=H2O for Ni(II) and H2L=H2L-1 or H2L-2) have been characterised by magnetic susceptibility measurements, electrical conductance values, and spectral properties. The magnetic moment value of [M(HL2)] (M=MnII, NiII, FeII or CuII) type complexes is consistent with high spin octahedral structure while those of [M(H2L)X2] (M=CoII, NiII, CuII, ZnII, or CdII, X=Cl− or Br−) possess five coordinated trigonal bipyramidal geometry. The adduct complexes [MLB]·nB (M=NiII, or CuII, B=H2O, Py, or Y-pic) are four coordinated planar and those of ZnII and CdII complexes [MLB], (H2L=H2L-1 or H2L-2, B=H2O, Py or Y-pic) are tetrahedral. These ligands have been suggested to coordinate as tridentate (N N S) donor molecule in complexes of type [M(H2L)X2], [M(HL)2], and [MLB]. The antifungal activity of ligands and some of their metal complexes were studied and it was observed that metal complexes show higher activity than free ligand.

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Section: Methodsmentioning

confidence: 99%

Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions

Bala

Mishra

2014

International Journal of Inorganic Chemistry

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“…For background to pyrazole derivatives and their uses, see: Ramaiah et al (1999). Table 1 Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

2-[5-(2-Fluorophenyl)-3-isobutyl-1H-pyrazol-1-yl]benzoic acid

Sreenivasa¹,

ManojKumar²,

Suchetan³

et al. 2013

Acta Cryst E

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“…The synthesis of benzimidazolyl-chalcones (6a-z) was made from 2-acetylbenzimidazole 4 [15] (figure 2). This compound was obtained in two steps from ophenylenediamine 1.…”

Section: Experimental Chemistrymentioning

confidence: 99%

Synthesis and anthelmintic activity of some hybrid Benzimidazolyl-chalcone derivatives

Ouattara¹,

Sissouma²,

Koné³

et al. 2011

Trop. J. Pharm Res

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Purpose: To synthesize hybrid benzimidazolyl-chalcone derivatives, evaluate their anthelmintic activity, and establish some structural elements which could lead to induction and enhancement of this activity. Methods: A series of 1-(1H-benzimidazol-2-yl)-3-aryl-2-propen-1-one compounds (6a-z) was synthesized by condensation reaction of 2-acetylbenzimidazole with aryl and heteroaryl aldehyde derivatives. The physicochemical characterization of these benzimidazolyl-chalcones was carried out by nuclear magnetic resonance spectroscopy ( 1 H and 13 C NMR) and mass spectroscopy (MS). All compounds were screened in vitro for their nematicidal activity against Haemonchus contortus in larval development assay. The anthelmintic activities obtained were compared with those of anthelmintic reference drugs (fenbendazole and ivermectin); 1,3-diphenyl-2-propen-1-one also used as reference for chalcone. Results: Compounds 6a, 6g, 6w and 6y showed good nematicidal activity (LC100) at 0.002 and 0.0092 µg/ml. The activity of these four benzimidazolyl-chalcones is nearly equal to that of fenbendazole. It is also interesting to know that these compounds have anti-haemonchus activity which is equal or more efficient than ivermectin. Four other compounds (6d, 6h, 6o and 6t) possess interesting anthelmintic activities at 0.68 and 0.16 µg/ml. Conclusion: Preliminary structure-activity relationship studies revealed that arylpropenone group in position 2 of the benzimidazole ring can be considered as new pharmacophore for nematicidal activity.

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ChemInform Abstract: Studies on Synthesis of 2‐Acetylbenzimidazole and Related Benzimidazole Derivatives.

Cited by 6 publications

References 1 publication

Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions

Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions

2-[5-(2-Fluorophenyl)-3-isobutyl-1H-pyrazol-1-yl]benzoic acid

Synthesis and anthelmintic activity of some hybrid Benzimidazolyl-chalcone derivatives

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