ChemInform Abstract: Structure—Activity Relationship Study of Asiatic Acid Derivatives Against Beta Amyloid (Aβ)‐Induced Neurotoxicity.

Jew, Sang‐sup; Yoo, Chi-hyoung; Lim, Doo-yeon; Kim, Heeman; Mook‐Jung, Inhee; Jung, Min Whan; Choi, Hayun; Jung, Young Hoon; Kim, Heedoo; Park, Hyeung‐geun

doi:10.1002/chin.200020156

Cited by 1 publication

(2 citation statements)

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“…AA inhibited the Aβ-induced cell death under in vitro conditions, through its anti-oxidative and anti-apoptotic actions (42). Jew et al, (19) indicated that various derivatives of AA exhibited protective activity at different levels against Aβinduced neurotoxicity in vitro. AA significantly downregulated the expression of β-secretase and upregulated the expression of α-secretase in primary rat cortical neurons (43), which is corroborated with our present results.…”

Section: Discussionmentioning

confidence: 99%

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Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer rsquo s disease

et al. 2018

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Alzheimer's disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied by diffuse structural abnormalities in the brain of elderly people. The current investigation explored the neuroprotective potential of asiatic acid (AA), a natural triterpene of on aluminium chloride (AlCl) induced rat model of AD. Oral administration of AlCl (100 mg/kg b.w.) for 42 days significantly elevated the levels of Al, activity of acetyl cholinesterase and expressions of amyloid precursor protein, amyloid beta, beta and gamma secretases, glial fibrillary acidic protein, ionized calcium binding adaptor molecule 1, interleukins -1β, 6, 4, 2, tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor- k beta and cyclooxygenase-2 in the hippocampus and cortex compared to the control group. Our observations suggested that AA treatment mitigated AlCl induced AD associated pathologies, which might be due to its multiple pharmacological actions. Further studies are necessary in order to explore the link between AlCl-mediated oxidative stress and associated apoptosis to establish its neuroprotective role in AD.

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Section: Discussionmentioning

confidence: 99%

“…Krishnamurthy et al (14) reported that asiatic acid (AA), a tri-terepene of CA could transverse the blood-brain barrier and mitigated mitochondrial injury in a mouse model of focal cerebral ischemia. Many previous studies revealed that this compound was a potent protective agent for brain against various neurotoxins (15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%