ChemInform Abstract: Rapid and Efficient Synthesis of 3,3‐Di(1H‐indol‐3‐yl)indolin‐2‐ones and 2,2‐Di(1H‐indol‐3‐yl)‐2H‐acenaphthen‐1‐ones Catalyzed by p‐TSA.

Abstract

Rapid and Efficient Synthesis of 3,3-Di(1H-indol-3-yl)indolin-2-ones and 2,2-Di(1H-indol-3-yl)-2H-acenaphthen-1-onesCatalyzed by p-TSA. -The title compounds (III) and (V) are obtained by reaction of various isatins or acenaphthenequinone, resp., with indoles under mild reaction conditions. -(YU, J.; SHEN, T.; LIN, Y.; ZHOU, Y.; SONG*, Q.; Synth.

Silica-Coated Magnetic-Nanoparticle-Supported DABCO-Derived Acidic Ionic Liquid for the Efficient Synthesis of Bioactive 3,3-Di(indolyl)indolin-2-ones

“…In this context, numerous metal salts and complexes, such as Bi(OTf) 3 , 7 Zn(OTf) 2 , 8 Zr(salphen)Cl 2 , 9 FeCl 3 , 2 and (NH 4 ) 2 [Ce(NO 3 ) 6 ], 10 have produced the desired indolinones in good to excellent yields. A range of other acid catalysts such as p-toluenesulfonic acid, 11 sulfamic acid, 12 and Wells− Dawson-type tungstophosphoric heteropolyacid 13 have also been utilized to carry out the synthesis. However, most of the above methods are associated with one or more drawbacks, such as the use of exhaustible metal reserves, harsh and corrosive acids, tedious workup procedures, and unrecyclable catalysts.…”