ChemInform Abstract: PREPARATION OF SOME 1,2,3,4‐TETRAZOLES

Cowper, A. J.; Astik, R. R.; Thaker, K. A.

doi:10.1002/chin.198217204

Cited by 3 publications

(3 citation statements)

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“…On the other hand, five‐membered heterocyclic compounds, natural as well as synthetic, are important for their biological activities. Compounds with thiatriazole rings are of interest due to their broad spectrum of biological activities, such as antihypertensive 7, antibacterial 8, antifungal 9, antitubercular 10, fungicidal 11, and anticancer activities 12. Further, it has been reported that many biologically active natural and synthetic products have interesting molecular symmetry 13.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of 1,ω‐Bis(1,2,3,5‐thiatriazol‐5‐yl)alkanes as In Vitro and In Vivo α‐Amylase and Lipase Inhibitors

Hamzaoui

Hamden

Salem

et al. 2013

Archiv der Pharmazie

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Thionyl chloride reacts with 1,ω-bis-(1-tosylamidrazone)alkanes 1 to give a series of 1,ω-bis-(4-alkyl-2-tosyl-1,2,3,5-thiatriazol-5-yl)alkanes 2. All the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis, and ESI-MS spectral data. All the new compounds were screened for their inhibitory effect on key enzymes related to diabetes and obesity, such as α-amylase and lipase. In vitro and in vivo studies revealed that these thiatriazole derivatives exert an inhibitory action against these key enzymes. Moreover the administration of these compounds to surviving diabetic rats induced a significant decrease in plasma glucose level. Additively 2d significantly protected the liver-kidney functions and modulated lipid metabolism, which were evidenced by the decrease in aspartate transaminase (AST), alanine transaminase (ALT), and gamma-glutamyl transpeptidase (GGT) activities and creatinine, urea albumin, LDL-cholesterol and triglycerides levels as well as an increase in the HDL-cholesterol level in surviving diabetic rats. Overall, the findings of the current study indicate that 2d exhibits attractive properties and can, therefore, be considered for future application in the development of anti-diabetic and hypolipidemic drugs.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of 1,ω‐Bis(1,2,3,5‐thiatriazol‐5‐yl)alkanes as In Vitro and In Vivo α‐Amylase and Lipase Inhibitors

Hamzaoui

Hamden

Salem

et al. 2013

Archiv der Pharmazie

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“…1 Several Palladium (II) complexes having thioamide ligands are reported to be potential antitumor activity [2][3] and significant antifungal activity 4 . Cowper and Co-workers 5 have examined the antimicrobial activity of some 1,2,3,4-Tetrazole having thioamide group. The present paper aims at structural and biological evaluation of some Palladium (II) complexes ligated by 1-substituted phenyl-tetrazoline-5-thione.…”

Section: Introductionmentioning

confidence: 99%

Structural and Anti-Fungal Evaluation of Palladium(II) Complexes Ligated by Triphenyl Phosphine and Isomeric 1-substituted phenyl tetrazoline-5-thione

Pandey¹,

Kumar²,

Shahi³

et al. 2013

Orientjchem.

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A series of phosphine complexes of palladium (II) ligated with 1-substituted phenyl tetrazoline-5-thione have been prepared and identification of complexes are established on the basis of elemental analysis, magnetic susceptibility, conductivity, IR, UV-vis and 1 H NMR spectral data. The phenyl ring was substituted to correlate the electronic effect of such substituents on the magnitude of the anti-fungal activity against Aspergillus favus species.Key words: Palladium (II), Thioamides, antifungal activity, structure and Bonding such substituents on the magnitude of the bioactivities.

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“…2 For example, mono-substituted aminothiatriazoles (4 in Scheme 1) exhibit a wide range of interesting biological properties, including antihypertensive, 3 antibacterial, 4 antitubercular, 5 antiviral, 6 fungicidal, 7 anticancer, 8 central nervous system stimulant, and muscle relaxant activities. 9 Among currently available synthetic routes to mono-substituted aminothiatriazoles, the most widely used one is based upon the method outlined originally by Freund and his co-workers, 10 which involves the treatment of thiosemicarbazides with nitrous acid.…”

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confidence: 99%

Synthesis of Mono-substituted 5-Aminothiatriazoles and Their Conversion to Tetrazole-5-thiones

Lee¹,

Kim²,

Kim³

et al. 2012

Bulletin of the Korean Chemical Society

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ChemInform Abstract: PREPARATION OF SOME 1,2,3,4‐TETRAZOLES

Abstract: Die Umsetzung der Thiosemicarbazide (I) mit salpetriger Säure (II) ergibt die Thiatriazole (III), die unter basischen Bedindungen zu den entsprechenden Tetrazolthiolen (IV) isomerisieren.

Cited by 3 publications

References 0 publications

Synthesis and Evaluation of 1,ω‐Bis(1,2,3,5‐thiatriazol‐5‐yl)alkanes as In Vitro and In Vivo α‐Amylase and Lipase Inhibitors

Synthesis and Evaluation of 1,ω‐Bis(1,2,3,5‐thiatriazol‐5‐yl)alkanes as In Vitro and In Vivo α‐Amylase and Lipase Inhibitors

Structural and Anti-Fungal Evaluation of Palladium(II) Complexes Ligated by Triphenyl Phosphine and Isomeric 1-substituted phenyl tetrazoline-5-thione

Synthesis of Mono-substituted 5-Aminothiatriazoles and Their Conversion to Tetrazole-5-thiones

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