ChemInform Abstract: Pharmaceutical Applications of Supercritical Carbon Dioxide

Kaiser, Claudia; Roempp, H.; Schmidt, Peter

doi:10.1002/chin.200212298

Cited by 12 publications

(13 citation statements)

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“…Modern extraction techniques were selected which, once the process is established, can easily be scaled-up to an industrial level and provide high-quality extracts while protecting the environment. The Sc-CO 2 extraction represents the method of choice for the isolation of lipophilic components [29]. The spray drying process has proved to be the superior and efficient method because it is multiple times cheaper compared to freeze drying and provides extracts of extended stability with the possibility of concealing unpleasant odors and tastes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anticancer Activity of Satureja montana Supercritical and Spray-Dried Extracts on Ehrlich’s Ascites Carcinoma Bearing Mice

Vladić

Ćebović

Vidović

et al. 2020

Plants

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Satureja montana herbal species belongs to aromatic medicinal plants with a significant place in traditional medicine. However, products produced with conventional procedures do not meet the requirements of the modern market which include environmentally-safe processes that provide quality, safe, and standardized products. In this study, the antiproliferative activity of S. montana extracts obtained by supercritical carbon dioxide and solid–liquid extraction followed by spray drying was investigated using the in vivo model of Ehrlich ascites carcinoma (EAC) in mice. The impact of two concentrations of extracts on the growth of tumor and the redox status of malignant cells was monitored. It was determined that the extracts induced oxidative stress in the malignant cells which was confirmed by the changes in activity of biochemical indicators of oxidative stress. The posttreatment was not an efficient approach, while the extracts applied as pretreatment and treatment resulted in an increase in the xanthine oxidase (XOD) activity, a decrease in catalase (CAT) activity, and an increase in the intensity of lipid peroxidation (LPx). Furthermore, a decrease in the values of reduced glutathione (GSH) and an increase in glutathione reductase (GR) and glutathione peroxidase (GSHPx) in EAC cells were recorded.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Anticancer Activity of Satureja montana Supercritical and Spray-Dried Extracts on Ehrlich’s Ascites Carcinoma Bearing Mice

Vladić

Ćebović

Vidović

et al. 2020

Plants

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“…The supercritical fluid has distinct thermophysical properties which can be finely adjusted by minute modifications in the pressure. It is solvent-free processing (Chen et al, 2006;Kaiser et al, 2001). With the elevation in pressure, the density and capability of fluid to liquefy compounds enhance, whereas the velocity remains the same.…”

Section: Supercritical Fluid (Scf)mentioning

confidence: 99%

Solid lipid nanoparticles: Preparation techniques, their characterization, and an update on recent studies

2020

J app pharm sci

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Solid lipid nanoparticles (SLNs) have emerged as a remarkable nanocolloidal system for drug delivery. This review presents contemporary information regarding various aspects about SLNs, i.e., SLN morphology, structural features, preparatory methods, and their characterizations. This carrier system allows advancing the therapeutic efficacy of drugs belonging to several categories. The present uses of SLNs include cancer therapy, infectious conditions, diabetes, central nervous system disorders, cardiovascular disorders, cosmeceuticals, and others. SLNs facilitate improved the pharmacokinetics and modify the drug releases. The prospect of surface modification, enhanced permeation against various biological barriers, the ability to resist chemical degradation, and the possibility of encapsulation of two or more therapeutic agents simultaneously has gained attention for SLNs universally. Simultaneously, this review emphasizes on recent research trends pertaining to this carrier system.

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“…The advantage of solid lipid nanoparticles is that they can be formulated in the optimal pH range. During the preparation of topical formulation, the osmotic effects to be taken into consideration because change in isotonicity can cause irritation to skin …”

Section: Osmotic Effects and Control Of Phmentioning

confidence: 99%

“…During the preparation of topical formulation, the osmotic effects to be taken into consideration because change in isotonicity can cause irritation to skin. 50…”

Section: Of Phmentioning

confidence: 99%

Role of solid lipid nanoparticles as photoprotective agents in cosmetics

Jose

Netto

2018

J of Cosmetic Dermatology

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The disadvantages of conventional sunscreens can be overcome by incorporation of solid lipid nanoparticles. On comparing the lipid nanobased systems with traditional cosmetic products, the occlusion can be achieved without the use of paraffin and other greasy oils. The film formed by lipid nanoparticles will be smooth as compared to the inflexible films formed by the paraffin. Newer approaches may lead to even better results. They also possess excellent UV-blocking activity and showed better photoprotection.

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ChemInform Abstract: Pharmaceutical Applications of Supercritical Carbon Dioxide

Cited by 12 publications

References 0 publications

Evaluation of Anticancer Activity of Satureja montana Supercritical and Spray-Dried Extracts on Ehrlich’s Ascites Carcinoma Bearing Mice

Evaluation of Anticancer Activity of Satureja montana Supercritical and Spray-Dried Extracts on Ehrlich’s Ascites Carcinoma Bearing Mice

Solid lipid nanoparticles: Preparation techniques, their characterization, and an update on recent studies

Role of solid lipid nanoparticles as photoprotective agents in cosmetics

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