ChemInform Abstract: PALLADIUM‐CATALYZED ARYLATION AND VINYLATION OF 1,4‐DIENES

Abstract

1,4‐Diene werden in′ Gegenwart von Palladium‐Katalysatoren und sekundären Aminen einer Arylierung oder Vinylierung unterworfen.

Construction of Azaheterocycles via Pd-Catalyzed Migratory Cycloannulation Reaction of Unactivated Alkenes

“…Numerous [n+2] reactions for the synthesis of 5-, 6-membered azaheterocycles have been reported with highly reactive styrene, 1,3-diene, allene, and strained cyclic alkene, in which the cyclization normally occurred at the vicinal 1,2-position of those alkenes (Figure 1b). In sharp contrast, the transition metal-catalyzed migratory cycloannulation, the cyclization happens at the remote (1,n)-position of the unactivated alkenes, is barely mentioned in the literatures 32,33 (Figure 1c). Overcoming the limitation of the vicinal 1,2-functionalization of alkenes in transition metal-catalyzed [n+2] cyclisation reactions will open a new avenue for the rapid construction of diverse azaheterocycles, and will find wide synthetic applications in pharmaceutical industry.…”