ChemInform Abstract: One‐Pot Multicomponent Synthesis of Diversely Substituted 2‐Aminopyrroles. A Short General Synthesis of Rigidins A, B, C, and D.

Abstract

Base-mediated coupling of sulfonamides of type (I) and (V) with aldehydes and activated cyanides allows new access to tetra-and pentasubstituted 2-aminopyrroles. Some of them show anticancer or antibacterial activity. The method can be applied successfully to prepare the rigidin alkaloids A, B, C, and D (XIII). -(FROLOVA, L. V.; EVDOKIMOV, N. M.; HAYDEN, K.; MALIK, I.; ROGELJ, S.; KORNIENKO, A.; MAGEDOV*, I. V.; Org. Lett. 13 (2011) 5, 1118-1121, http://dx.doi.org/10.1021/ol103149b ; Dep. Chem., N. Mex. Inst. Min. Technol., Socorro, NM 87801, USA; Eng.) -Jannicke

Synthesis of 2‐Substituted 2‐Amino Ketones by Rhodium‐Catalyzed Reaction of N‐Sulfonyl‐1,2,3‐triazoles with 2‐Alkenols

“…[3] They also act as the key intermediate for the synthesis of chiral 2-amino alcohols [4] and various nitrogencontaining heterocycles. [5] Thus, the development of an efficient method to synthesize this functionality, starting from readily available compounds is highly demanded. [6] We have been studying various rhodium(II)-catalyzed reactions of N-sulfonyl-1,2,3-triazoles.…”