ChemInform Abstract: Non‐Peptide Angiotensin II Receptor Antagonists: Synthesis and Biological Activity of a Series of Novel 4,5‐Dihydro‐4‐oxo‐3H‐imidazo( 4,5‐c)pyridine Derivatives.

Abstract

Non-Peptide Angiotensin II Receptor Antagonists: Synthesis and Biological Activity of a Series of Novel 4,5-Dihydro-4-oxo-3H-imidazo( 4,5-c)pyridine Derivatives.-A series of title compound derivatives is synthesized and tested for their biological activity in vitro tests. Small alkyl groups at C-2 and the (methylbiphenylyl)tetrazole moiety at N-3 are found to show best results. Also replacement of the N-5 hydrogen with acetic esters or acetamide increases the activity. Compound (VI) is superior to the orally active Ang II antagonist losartan. -(MEDERSKI, W. W. K. R.; DORSCH, D.; BOKEL, H.-H.; BEIER, N.; LUES, I.; SCHELLING, P.; J. Med. Chem. 37 (1994) 11, 1632-1645; Preclin. Pharm. Res. Cent. Process Dev.,