ChemInform Abstract: NMR‐Controlled Titrations of Phosphorus‐Containing Acids and Bases in Protolysis and Complex Formation

Abstract

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Protolysis and Complex Formation of Organophosphorus Compounds—Characterization by NMR-Controlled Titrations

“…Phosphonocarboxylic acids HOOC-(CH 2 ) n -PO 3 H 2 gave rise to potentiometrically [4,44] and NMR-controlled titrations [4,28,31,44]. Those neutral acids of type H 3 L deprotonate dominantly in a sequence: HOOC-(CH 2 ) n -PO 3 H 2 → − OOC-(CH 2 ) n -PO 3 H − → − OOC-(CH 2 ) n -PO 3 2− .…”

“…A brief overview of “ 31 P NMR controlled titrations of Phosphorus-Containing Acids and Bases in Protolysis and Complex Formation” reported about the 81 MHz 31 P{ 1 H} NMR titration of phosphonoacetic acid [28]. The hardware and software concepts were shown.…”

Synthesis, NMR‐Spectroscopy, and Molecular Structure of a Phosphonyl Ene Diamine

“…In fact α‐aminophosphonic acids and their derivatives display significant biological activities in a wide range acting as effective aminopeptidase inhibitors,9 antiviral agents,10 antioxidants,11,12 antibiotics,13,14 pesticide candidates15 (herbicides12,16 or plant growth regulators17) as well as anti‐HIV agents 18. The protolytic behavior and complex formation of aminophosphonates were characterized by potentiometric and novel methods for automated NMR spectroscopy‐controlled titrations leading to stability constants and ion‐specific NMR parameters 19,20. Consequently aminophosphonates can be used as valuable tools to follow pH changes during biological processes in the living organism by 31 P NMR spectroscopy 21.…”