ChemInform Abstract: New Reactive Pyridinium‐Indolizines Fluorophores

Furdui, Bianca; Dinică, Rodica Mihaela; Demeunynck, Martine; Druţă, I.; Vlahovici, A.

doi:10.1002/chin.200816162

Cited by 4 publications

(4 citation statements)

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“…UV-Vis spectra in the scanning range of 200-700 nm for all aqueous solutions with and without lipase were recorded. The absorption peak for Lr and Lm is at 264 nm (UV), the maximum wavelength (λ max ) being caused by the π → π* electron transition of benzene ring, which is in accordance with references [1,26]. The absorbance indicates a shift for both ligands aqueous solutions when in contact with lipase.…”

Section: Temperature Effect On Pyridinium Ligands In the Absence And supporting

confidence: 86%

“…Pyridinium ligands are very interesting compounds with many applications and they have significant antimicrobial properties, being involved in the inhibition of microorganism growth (bacteria and fungus) [1,2]. Also, the compounds are used as electronic transporters, biological redox indicators [3], model systems in photosynthesis [4], cardiovascular, hypotensive [5] and neuromuscular agents [6], catalysts [7], acylation agents and ionic liquids [8].…”

Section: Introductionmentioning

confidence: 99%

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The interactions between lipase and pyridinium ligands investigated by electrochemical and spectrophotometric methods

Patriche

Lupu

Cârâc

et al. 2016

J. Electrochem. Sci. Eng.

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The interaction between pyridinium ligands derived from 4,4’-bipyridine (N,N’-bis(p-bromophenacyl)-4,4’-bipyridinium dibromide – Lr) and (N,N’-bis(p-bromophenacyl)-1,2-bis (4-pyridyl) ethane dibromide – Lm) with lipase enzyme was evaluated. The stability of the pyridinium ligands, having an essential role in biological systems, in 0.1 M KNO3 as supporting electrolyte is influenced by the lipase concentration added. The pH and conductometry measurements in aqueous solution suggest a rapid ionic exchange process. The behavior of pyridinium ligands in the presence of lipase is investigated by cyclic voltammetry and UV/Vis spectroscopy, which indicated bindings and changes from the interaction between them. The voltammograms recorded on the glassy carbon electrode showed a more intense electronic transfer for the Lr interaction with lipase compared to Lm, which is due to the absence of mobile ethylene groups from Lr structure.

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Section: Temperature Effect On Pyridinium Ligands In the Absence And supporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

The interactions between lipase and pyridinium ligands investigated by electrochemical and spectrophotometric methods

Patriche

Lupu

Cârâc

et al. 2016

J. Electrochem. Sci. Eng.

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“…A number of biologically important natural products contain the indolizine framework . As a result, a variety of methods for their synthesis have emerged. , One of these strategies is the transition-metal-catalyzed cycloisomerization of easily available nonconjugated propargylpyridines or other organic molecules into indolizines . Transition-metal-catalyzed cycloisomerizations typically proceed through metal–carbene intermediates .…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Study of Indolizine Heterocycle Formation by Ruthenium(II)-Assisted Three-Component Cross-Coupling/Cyclization

Zhang

et al. 2013

Organometallics

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In the presence of the acid HBF 4 , 3-alkenyl-2-phosphonium indolizines 3a−c can be produced respectively by adding PhCCCOCH 3 (2a), CH 3 OCOCCCOOCH 3 (2b), and CH 3 CH 2 CCCOCH 3 (2c) to a mixture of ruthenium complex RuCl 2 (PPh 3 ) 3 and the propargyl alcohol (2-Py)CH(OH)CCH (1). We carefully investigated the mechanism of this reaction by means of structurally characterizing two key intermediates, ruthenium vinyl (4) and ruthenium carbene (5), and by deuterium-labeling experiments. A plausible mechanism is proposed, which involves addition of a proton to an alkyne carbon and the insertion of an alkyne into the Cα bond of an alkenylcarbene group, followed by an α-H elimination and reductive elimination.

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“…They present applications in pharmaceutical area being used in drug and gene delivery and as cardiovascular agents [13,14]. The pyridinium quaternary salts are precursors for the synthesis of fluorescent indolizine compounds that exhibit valuable biological activity [14,15]. Some of the pyridinium salts were found to be ionic liquids [6,14].…”

mentioning

confidence: 99%

Solvent Effects on the Spectral and Electrochemical Properties of Some Pyridinium Quaternary Compounds

Cârâc¹,

Boscencu²,

Botezatu³

et al. 2017

Rev. Chim.

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The physicochemical properties and the redox potential of two pyridinium compounds, a diquaternary salt of 4,4�-bipyridinium (BP) and one of 1,2-bis(4-pyridyl)ethane (BPE) were studied. Cyclic voltammetry on platinum electrode was used to evaluate the solvent influence on the redox properties of the pyridinium compounds. Electrochemical measurements were performed in aqueous media, ethanol and aprotic solvent. The solvent variation causes changes in the electro-oxidation processes of the heterogeneous electron transfer at the applied potential. The presence of the ethylenic group in the structure of BPE presents slightly different electrochemical behaviour compared to BP. The corroboration of the electrochemical data with absorption spectral results attests that it�s more likely that the ECE sequence is responsible for the reduction mechanism of pyridinium compounds.

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ChemInform Abstract: New Reactive Pyridinium‐Indolizines Fluorophores

Cited by 4 publications

References 0 publications

The interactions between lipase and pyridinium ligands investigated by electrochemical and spectrophotometric methods

The interactions between lipase and pyridinium ligands investigated by electrochemical and spectrophotometric methods

Mechanistic Study of Indolizine Heterocycle Formation by Ruthenium(II)-Assisted Three-Component Cross-Coupling/Cyclization

Solvent Effects on the Spectral and Electrochemical Properties of Some Pyridinium Quaternary Compounds

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