ChemInform Abstract: New Isocoumarins from a Cold‐Adapted Fungal Strain Mucor sp. and Their Developmental Toxicity to Zebrafish Embryos.

Feng, Chun-Chi; Chen, Guodong; Zhao, Yanli; Xin, Sheng‐Chang; Song, Li; Tang, Jinshan; Li, Xiaoxia; Hu, Dan; Liu, Xing‐Zhong; Gao, Hao

doi:10.1002/chin.201504228

Cited by 1 publication

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“…In 2001, both 18 and its methyl derivative were first reported from saprophytic fungus Aspergillus ochraceus yielding the important mycotoxin ochratoxin A . In 2014, 18 and its nine analogs were reported from a cold‐adapted fungus Mucor sp . In 2016, 18 , together with two hydroxy analogs of 19 , was reported from an endophytic fungus Botryosphaeria sp.…”

Section: Resultsmentioning

confidence: 99%

Metabolites from Two Dominant Thermophilic Fungal Species Thermomyces lanuginosus and Scytalidium thermophilum

Yang

Zhang

Ding

et al. 2020

Chemistry & Biodiversity

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Thermomyces lanuginosus and Scytalidium thermophilum are among the most ubiquitous thermophilic fungi in compost and soil. Chemical study on these two prevalent strains collected from Yunnan led to isolation of 23 metabolites, including one new metabolite, therlanubutanolide, and 15 known compounds, isolated from the YGP culture broth of Thermomyces lanuginosus and 7 known compounds isolated from Scytalidium thermophilum, respectively. Therlanubutanolide shared the quite similar features of the same carbon skeleton and saturation as natural hexadecanoic acids. This was the first reported discovery of such a lactone as natural occurring metabolite. All the compounds were reported for the first time from thermophilic fungi. Among them, N-[(2S,3R,4E,8E)-1,3-dihydroxy-9-methyloctadeca-4,8-dien-2-yl]acetamide was for the first time reported to be a naturally occurring metabolite and its NMR data was first provided in this study. A type of PKS-derived metabolites, three 3,4-dihydronaphthalen-1(2H)-ones, which were widely found in plant pathogenic fungi as phytotoxins and reported to have antimicrobial activity, were obtained from both dominant thermophilic fungi. The frequent occurrence of such PKS phytotoxins in these two thermophilic fungi might suggest particular ecological interest.

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Section: Resultsmentioning

confidence: 99%

Metabolites from Two Dominant Thermophilic Fungal Species Thermomyces lanuginosus and Scytalidium thermophilum

Yang

Zhang

Ding

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: New Isocoumarins from a Cold‐Adapted Fungal Strain Mucor sp. and Their Developmental Toxicity to Zebrafish Embryos.

Abstract: Three new isocoumarin derivatives, mucorisocoumarins A‐C, are isolated along with seven known compounds.

Cited by 1 publication

References 1 publication

Metabolites from Two Dominant Thermophilic Fungal Species Thermomyces lanuginosus and Scytalidium thermophilum

Metabolites from Two Dominant Thermophilic Fungal Species Thermomyces lanuginosus and Scytalidium thermophilum

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