ChemInform Abstract: NEW 4‐PYRIDONYL‐ACETAMIDO‐CEPHALOSPORINS AND RELATED COMPOUNDS

Abstract

Aus den substituierten Pyridon‐N‐essigsäuren (I) und den Cephalosporinestern (II) werden die Acetamidocephalosporine (III) synthetisiert, die mit Mercaptoheterocyclen in die Cephalosporinderivate (IV) übergehen.

.BETA.-Lactam antibiotics derived from nitrogen heterocyclic acetic acids. 2. Cephalosporin derivatives.

“…The penicillin derived from 1,4-dihydro-4-oxopyridine-l-acetic acid (1) The zwitterionic nature of 1 necessitated the use of a polar solvent (DMF) in coupling reactions with 7-aminocephalosporanic acid derivatives. We found the reagent of choice to be carbonyldiimidazole (CDI).…”