ChemInform Abstract: NEUTRAL IONOPHORES WITH SELECTIVITY FOR SODIUM ION

Abstract

Die Darstellung der neuen, nicht‐makrocyclischen, elektrisch neutralen Ionophore (V)‐(IX) wird beschrieben.

A General and Mild Ullmann‐Type Synthesis of Diaryl Ethers.

“…The crude oily residue was purified by flash chromatography on silica gel (eluent: hexanes) to provide 399 mg (94 % yield) of the desired product as an orange oil. 12) 2,2'-dimethyl-diphenylether 14 Experimental procedure (Table 5, entry 17) Following the general procedure (110 °C, 35 hours), o-cresol (206 µL, 2.0 mmol) was coupled with 2iodotoluene (383 µL, 3.0 mmol) using cesium carbonate (1.303 g, 4.0 mmol), Cu 2 O (14.4 mg, 0.1 mmol), Chxn-Py-Al (117 mg, 0.4 mmol), activated and powdered 3 Å molecular sieves (600 mg), and DMF (1.2 mL). The crude oily residue was purified by flash chromatography on silica gel (eluent: hexanes) to provide 389 mg (98 % yield) of the desired product as a colorless oil.…”