ChemInform Abstract: Kinetic Resolution of the Racemic 2‐Hydroxyalkanoates Using the Enantioselective Mixed‐Anhydride Method with Pivalic Anhydride and a Chiral Acyl‐Transfer Catalyst.

Abstract

. -Both optically active 2-acyloxyalkanoates and 2-hydroxyalkanoates are prepared under optimized conditions concerning the achiral carboxylic acid and the carboxylic anhydride. The mixed anhydrides generated from diphenylacetic acid and pivalic anhydride under the influence of (R)-benzotetramisole BTM are transacylated with high chemoselectivities to give the desired resolved alkanoates.