ChemInform Abstract: ISOLATION AND STRUCTURE OF PSEUROTIN A, A MICROBIAL METABOLITE OF PSEUDEUROTIUM OVALIS STOLK WITH AN UNUSUAL HETEROSPIROCYCLIC SYSTEM

Fumiquinones A and B, Nematicidal Quinones Produced byAspergillus fumigatus

“…The spectroscopic data for 4 and 5 have been previously reported. [13][14][15] Bioassay for nematicidal activity. Nematicidal activity was measured in microwell plates with the rootlesion nematode, Pratylenchus penetrans, the pine wood nematode, Bursaphelenchus xylophilus, and worms of the free-living nematode, Caenorhabditis elegans, according to the method of Kusano et al…”

“…Compounds 3-5 were identified as spinulosin, [10][11][12] LL-S490, 13) and pseurotin A, 14,15) respectively, by comparing their physicochemical properties with those reported (Fig. 1).…”

“…Our investigation of metabolites of this fungus has now led to the isolation of two novel active compounds, fumiquinones A (1) and B (2), together with spinulosin (3), [10][11][12] LL-S490 (4), 13) and pseurotin A (5). 14,15) The present paper describes the production, isolation, structural determination, and biological activities of 1-5.…”

Enhanced and sustained topical ocular delivery of cyclosporine A in thermosensitive hyaluronic acid-based in situ forming microgels

“…21,22 Over the past several years, numerous studies have shown the potential applications of CyA in ophthalmology. 23,24 Due to its high hydrophobicity and poor aqueous solubility, CyA cannot be formulated into the common aqueous formulations, leading to a low absorption and bioavailability.…”

Two new hetero-spirocyclic γ-lactam derivatives from marine sediment-derived fungus Aspergillus sydowi D2–6

“…The methyl proton H-24 at δ 2.00 exhibited a long-range coupling to sp 2 quaternary carbons C-2 (δ 172.5) and C-3 (δ 107.9), and carbonyl carbon C-4 (δ 195.6), suggesting the presence of an α, β-unsaturated carbonyl moiety. The long-range couplings from NH-7, H-9 and OH-9 to C-5, as well as the longrange couplings from H-9 to C-4 established the 1-oxa-7-azaspiro [4, 4] non-2-ene-4, 6-dione skeleton (Boot et al, 2007), similar to pseurotin A (Bloch and Tamm, 1981). The long-range couplings from H-9 to C-17 and from H-24 to C-14 established the total structure of 1.…”