ChemInform Abstract: Iodine‐Catalyzed Condensation of Isatin with Indoles: A Facile Synthesis of Di(indolyl)indolin‐2‐ones and Evaluation of Their Cytotoxicity.

Abstract

The title compounds (III) (15 examples) are smoothly obtained under mild reaction conditions and found to possess a strong and selective cytotoxicity against cancer cells.

Chemistry of trisindolines: natural occurrence, synthesis and bioactivity

“…The I 2 -catalyzed reaction showed a wide scope with electron-poor and electron-rich indoles. 7 In comparison, the method by Paira et al has advantages over Reddy et al 's method in terms of higher yields and shorter reaction times ( Scheme 17 ).…”

“…1 ). Since their first discovery, 6 trisindolines have attracted considerable attention due to their wide biological activities including anticancer, 7–9 antimicrobial, 10 antimycobacterial, 11 antifungal, 10 anticonvulsant, 10 α-glucosidase inhibition, 12 and spermicidal 13 activities. The 3,3-di(3-indolyl)-2-indolone 3 isomer is far more interesting than the 2,2-di(3-indolyl)-3-indolone 4 isomer due to its higher potency and potential as a drug lead compound.…”

MgO‐Nanoparticle‐Catalyzed Synthesis and Evaluation of Antimicrobial and Antioxidant Activity of New Multi‐Ring Compounds Containing Spiro[indoline‐3,4′‐[1,3]dithiine]

“…Indoles and its derivatives are found in abundance in nature and are well‐known for their physiological, pharmacologically and biological properties. Biological properties have also been reported from the oxindole derivatives . Spiro's heterocyclic compound has a vital biological activity due to the presence of a carbon between the two rings and the asymmetric nature of carbon spiros .…”

Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents

“…Isatin is a versatile lead molecule for designing potential antiviral agents. Isatin derivatives display broad spectrum pharmacological properties, including cytotoxic (Reddy et al, 2012;Alcaide et al, 2012), antibacterial (Akhaja and Raval, 2011), antifungal (Reddy et al, 2011), antiviral (Kang et al, 2011;Bacani et al, 2011;Sin et al, 2009), anti-HIV (Bal et al, 2005), and antimalarial (Hans et al, 2011) activities. The first clinically approved antiviral agent, N-methylisatin-b-thiosemicarbazone (methisazone) was active against smallpox and vaccinia viruses (Bauer, 1985).…”