ChemInform Abstract: Indazole‐3‐oles and Indazole‐2‐ones with Antiinflammatory Activity.

Abstract

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Investigation on Photophysical, Solvatochromism and Biological Significance of Substituted 2H‐Indazole Derivatives

“…[24] Many 2H-indazole containing compounds are potent kinase inhibitors [25][26][27] and anti-inflammatory drugs. [28,29] Till date, 2Hindazole is considered as a starting molecule or a building block for many drug discoveries and still lot of novel activities yet remain unexplored. N-heterocylic molecules are being extensively utilized as building blocks [30] for the construction of luminescent probes because of their interesting electron withdrawing properties upon photoexcitation.…”

“…Diversely substituted 2 H ‐indazole compounds with variously substituted functional groups, possess a wide spectrum of pharmacological activities and also serve as scaffolds for many drug molecules . Many 2 H ‐indazole containing compounds are potent kinase inhibitors and anti‐inflammatory drugs . Till date, 2 H ‐indazole is considered as a starting molecule or a building block for many drug discoveries and still lot of novel activities yet remain unexplored.…”

Facile synthesis of 1H-pyrazolo[1,2-a]pyridazine-5,8-dione derivatives by a one-pot, three-component reactions

“…[2][3][4][5][6] Among a large variety of nitrogencontaining heterocyclic compounds, heterocycles containing a bridgehead hydrazine functionality have received considerable attention because of their pharmacological properties and clinical applications. [7][8][9][10][11][12][13][14][15][16][17][18][19] For example, 1-hydroxy-, 1-amino-and 1-hydrazino-2,3-dihydro-1H-pyrazolo[1,2-a]pyridazine-5,8-diones 1 were reported to possess anti-inflammatory, analgesic, anti-hypoxic and anti-pyretic properties. 19 Furthermore, pyrazolidine compounds have been converted into azaproline amino acids, which have been studied upon incorporation into traditional peptides as well as small molecule peptidomimetics 2 (Scheme 1).…”

Effect of 3-(1H-Pyrrol-2-yl)-1H-Indazole on the Antioxidant Status of Rats

“…tolnidamine) was found to inhibit spermatogenesis and is contraceptive in rats after a single oral dose [2]. Indazole and their derivatives possess analgesic, antipyretic, and anti-inflammatory activities [3][4][5][6][7][8]. They also have antibacterial [9][10][11], antifungal [11], antihelminthic [12], and antiviral [13] properties.…”