Investigation on Photophysical, Solvatochromism and Biological Significance of Substituted 2H‐Indazole Derivatives

Abstract

The electronic properties of substituted 2H-indazoles were investigated for their photophysical behavior under isolated conditions and in solvent environment, both computationally and experimentally. DFT calculations with CAMÀ B3LYP functional and 6-311 + + G** basis set were performed in the ground and excited states. The effect of solvents on the low and high energy electronic states was studied by following the steady state absorption and fluorescence excitation and emission spectra. Solvatochromic interactions including general and specific solvent effects are reported along with the results of Lippert and E T (30) plots. The biological significance of these 2H-indazole derivatives was also investigated through docking studies. The interactions of 2H-indazole derivatives with the active site of subdomain II of human casein kinase (C2 K) alpha are reported.

Catalyst-free photoarylation of 2-aryl-2H-indazoles by carbon–iodine bond activation

“…3 In particular, 2-aryl-2 H -indazole derivatives exhibit a broad spectrum of biological activities. 4 They act as liver X receptor (LXR) agonists, estrogen receptor agonists, anti-inflammatory agents, viral polymerase inhibitors etc. (Fig.…”

New C‐3 Substituted 1H‐ and 2H‐Indazolephosphonic Acid Regioisomers: Synthesis, Spectroscopic Characterization and X‐Ray Diffraction Studies

“…Recently, indazole derivatives have gained attention in other areas, such as materials chemistry, due to their solvatochromism, electronic and photophysical properties, with potential applications as dyes, fluorescent probes and imaging agents. [25][26][27] Organophosphorus compounds are a class of compounds with diverse structural moieties, with a wide number of applications. [28][29][30] Among these organophosphorus compounds, phosphonates present a large diversity of applications, ranging from medicinal chemistry to materials sciences.…”